[1]:
import time
from pathlib import Path
import numpy as np
import pandas as pd
import matplotlib.pyplot as plt
import seaborn as sns
from scipy import stats
from sklearn.pipeline import make_pipeline
from sklearn.impute import SimpleImputer
from sklearn.preprocessing import StandardScaler
from sklearn.ensemble import RandomForestRegressor
import fdfi
print(fdfi.__version__)
from fdfi.explainers import EOTExplainer
0.0.5
Load Data And Feature Groups
[2]:
DATA_DIR = Path("data")
DATASETS = {
"sens50": {
"file": DATA_DIR / "sens50_processed_dataset.csv",
"target": "sens50",
},
"sens80": {
"file": DATA_DIR / "sens80_processed_dataset.csv",
"target": "sens80",
},
"ic50": {
"file": DATA_DIR / "ic50.censored_processed_dataset.csv",
"target": "ic50.censored",
},
}
outcome = "sens50"
cfg = DATASETS[outcome]
filename = str(cfg["file"])
data = pd.read_csv(cfg["file"])
y = data[cfg["target"]].astype(int)
X = data.drop(columns=[cfg["target"]])
df_groups = pd.read_csv(DATA_DIR / "feature_group.csv", index_col=0).set_index("feature")
df_groups = pd.get_dummies(df_groups["group"]).groupby(df_groups.index).max().reindex(X.columns)
print(f"Dataset shape: {X.shape}")
print(f"Target variable: {outcome}")
print(f"Number of groups: {len(df_groups.columns)}")
print(f"Data loaded from: {filename}")
Dataset shape: (611, 832)
Target variable: sens50
Number of groups: 14
Data loaded from: data/sens50_processed_dataset.csv
[3]:
print("Data preparation...")
preprocess = make_pipeline(
SimpleImputer(strategy="most_frequent"),
StandardScaler(),
)
X_values = preprocess.fit_transform(X)
y_values = y.values.astype(float)
# Standardize y to N(0,1) to match DFI paper (scale-invariant for z-scores
# but ensures the DFI UEIF formula (y - ỹ)² - (y - ŷ)² works in the same
# unit system as the reference implementation)
y_scaler = StandardScaler()
y_values = y_scaler.fit_transform(y_values.reshape(-1, 1)).ravel()
print("Data preparation finished")
print(f"Feature matrix shape: {X_values.shape}")
print(f"y statistics: mean={y_values.mean():.3f}, std={y_values.std():.3f}")
print(f"Missing values - X: {np.isnan(X_values).sum()}, y: {np.isnan(y_values).sum()}")
Data preparation...
Data preparation finished
Feature matrix shape: (611, 832)
y statistics: mean=-0.000, std=1.000
Missing values - X: 0, y: 0
[4]:
rf = RandomForestRegressor(
n_estimators=500,
max_depth=None,
min_samples_leaf=5,
random_state=0,
n_jobs=-1,
)
rf.fit(X_values, y_values)
model_fn = lambda X_: rf.predict(X_)
print(f"RandomForestRegressor fitted on full data")
print(f"Train R²: {rf.score(X_values, y_values):.3f}")
RandomForestRegressor fitted on full data
Train R²: 0.705
Fit EOT FDFI
[5]:
nsamples_main = 50
start_time = time.time()
fdfi_estimator = EOTExplainer(
model=model_fn,
data=X_values,
nsamples=nsamples_main,
epsilon=0.001,
sampling_method="resample",
random_state=0,
)
eot_results = fdfi_estimator(X_values, y=y_values)
dfi_time = time.time() - start_time
print(f"EOT FDFI completed in {dfi_time:.2f} seconds")
print(f"DFI scores shape: {eot_results['phi_X'].shape}")
np.sum(eot_results["phi_X"]), np.sum(eot_results["phi_Z"])
EOT FDFI completed in 434.01 seconds
DFI scores shape: (832,)
[5]:
(0.7396973904611802, 0.7396975752008004)
Individual Feature Inference With conf_int()
[6]:
ci_X = fdfi_estimator.conf_int(
alpha=0.05,
target="X",
var_floor_c=0.1,
var_floor_method="mixture",
var_floor_quantile=0.95,
margin=0.0,
margin_method="auto",
margin_quantile=0.95,
alternative="two-sided",
verbose=False,
)
ci_Z = fdfi_estimator.conf_int(
alpha=0.05,
target="Z",
var_floor_c=0.1,
var_floor_method="mixture",
var_floor_quantile=0.95,
margin=0.0,
margin_method="auto",
margin_quantile=0.95,
alternative="two-sided",
verbose=False,
)
Feature-Level Summary
[7]:
print("=== X-space feature summary ===")
_ = fdfi_estimator.summary(
alpha=0.05,
target="X",
var_floor_c=0.1,
var_floor_method="mixture",
var_floor_quantile=0.95,
margin=0.0,
margin_method="auto",
margin_quantile=0.95,
alternative="two-sided",
)
print("\n=== Z-space feature summary ===")
_ = fdfi_estimator.summary(
alpha=0.05,
target="Z",
var_floor_c=0.1,
var_floor_method="mixture",
var_floor_quantile=0.95,
margin=0.0,
margin_method="auto",
margin_quantile=0.95,
alternative="two-sided",
)
=== X-space feature summary ===
==============================================================================
Feature Importance Results
==============================================================================
Method: EOTExplainer
Number of units: 832
Significance level: 0.05
Alternative: two-sided
Margin method: mixture
Practical margin: 0.0028
------------------------------------------------------------------------------
Feature Estimate Std Err CI Lower CI Upper P-value Sig
------------------------------------------------------------------------------
0 0.0011 0.0018 -0.0026 0.0047 0.3314
1 0.0013 0.0019 -0.0023 0.0050 0.4123
2 0.0016 0.0018 -0.0020 0.0052 0.5027
3 0.0003 0.0018 -0.0032 0.0039 0.1639
4 0.0005 0.0018 -0.0031 0.0040 0.1935
5 0.0007 0.0018 -0.0029 0.0042 0.2342
6 0.0004 0.0018 -0.0031 0.0040 0.1831
7 0.0004 0.0018 -0.0032 0.0039 0.1751
8 0.0005 0.0018 -0.0031 0.0040 0.1914
9 0.0006 0.0018 -0.0029 0.0042 0.2180
10 0.0004 0.0018 -0.0031 0.0040 0.1829
11 0.0010 0.0019 -0.0026 0.0046 0.3183
12 0.0009 0.0018 -0.0027 0.0044 0.2734
13 0.0017 0.0018 -0.0019 0.0053 0.5164
14 0.0022 0.0018 -0.0014 0.0058 0.7177
15 0.0014 0.0019 -0.0023 0.0050 0.4212
16 0.0003 0.0018 -0.0033 0.0038 0.1569
17 0.0012 0.0018 -0.0023 0.0048 0.3699
18 0.0009 0.0018 -0.0027 0.0044 0.2722
19 0.0028 0.0018 -0.0008 0.0064 0.9783
20 0.0009 0.0018 -0.0027 0.0045 0.2861
21 0.0005 0.0018 -0.0031 0.0040 0.1884
22 0.0026 0.0018 -0.0010 0.0062 0.9030
23 0.0003 0.0018 -0.0032 0.0039 0.1617
24 0.0007 0.0018 -0.0029 0.0043 0.2367
25 0.0003 0.0018 -0.0032 0.0039 0.1639
26 0.0002 0.0018 -0.0033 0.0038 0.1486
27 0.0005 0.0018 -0.0031 0.0040 0.1925
28 0.0009 0.0018 -0.0026 0.0045 0.2895
29 0.0006 0.0018 -0.0029 0.0042 0.2164
30 0.0004 0.0018 -0.0031 0.0040 0.1771
31 0.0009 0.0018 -0.0027 0.0044 0.2789
32 0.0003 0.0018 -0.0032 0.0039 0.1643
33 0.0007 0.0018 -0.0029 0.0043 0.2353
34 0.0010 0.0018 -0.0025 0.0046 0.3114
35 0.0005 0.0018 -0.0030 0.0041 0.1991
36 0.0007 0.0018 -0.0028 0.0043 0.2418
37 0.0008 0.0018 -0.0028 0.0044 0.2594
38 0.0006 0.0018 -0.0029 0.0042 0.2163
39 0.0004 0.0018 -0.0032 0.0039 0.1704
40 0.0005 0.0018 -0.0031 0.0040 0.1862
41 0.0003 0.0018 -0.0032 0.0039 0.1641
42 0.0007 0.0018 -0.0029 0.0042 0.2333
43 0.0003 0.0018 -0.0033 0.0038 0.1568
44 0.0006 0.0018 -0.0030 0.0041 0.2126
45 0.0009 0.0019 -0.0028 0.0045 0.2809
46 0.0005 0.0018 -0.0031 0.0040 0.1882
47 0.0004 0.0018 -0.0032 0.0039 0.1720
48 0.0004 0.0018 -0.0032 0.0039 0.1749
49 0.0008 0.0018 -0.0027 0.0044 0.2713
50 0.0005 0.0018 -0.0031 0.0041 0.1961
51 0.0005 0.0018 -0.0030 0.0041 0.1997
52 0.0009 0.0018 -0.0027 0.0044 0.2728
53 0.0004 0.0018 -0.0031 0.0039 0.1759
54 0.0004 0.0018 -0.0031 0.0040 0.1844
55 0.0004 0.0018 -0.0031 0.0040 0.1793
56 0.0003 0.0018 -0.0033 0.0038 0.1573
57 0.0010 0.0018 -0.0025 0.0046 0.3164
58 0.0020 0.0018 -0.0016 0.0056 0.6612
59 0.0007 0.0018 -0.0028 0.0043 0.2359
60 0.0005 0.0018 -0.0030 0.0041 0.2028
61 0.0008 0.0018 -0.0028 0.0043 0.2488
62 0.0006 0.0018 -0.0030 0.0042 0.2164
63 0.0004 0.0018 -0.0031 0.0040 0.1775
64 0.0004 0.0018 -0.0031 0.0040 0.1784
65 0.0010 0.0018 -0.0026 0.0047 0.3283
66 0.0003 0.0018 -0.0032 0.0039 0.1646
67 0.0004 0.0018 -0.0032 0.0039 0.1750
68 0.0013 0.0018 -0.0024 0.0049 0.3907
69 0.0004 0.0018 -0.0031 0.0040 0.1808
70 0.0014 0.0018 -0.0022 0.0050 0.4354
71 0.0005 0.0018 -0.0031 0.0040 0.1879
72 0.0011 0.0018 -0.0025 0.0046 0.3263
73 0.0012 0.0018 -0.0023 0.0048 0.3746
74 0.0017 0.0021 -0.0025 0.0059 0.5913
75 0.0005 0.0018 -0.0031 0.0040 0.1895
76 0.0004 0.0018 -0.0031 0.0040 0.1807
77 0.0007 0.0018 -0.0029 0.0043 0.2320
78 0.0003 0.0018 -0.0032 0.0039 0.1628
79 0.0018 0.0019 -0.0020 0.0056 0.5870
80 -0.0002 0.0020 -0.0042 0.0037 0.1267
81 0.0002 0.0018 -0.0033 0.0038 0.1509
82 0.0004 0.0018 -0.0032 0.0039 0.1691
83 0.0004 0.0018 -0.0031 0.0040 0.1810
84 0.0003 0.0018 -0.0032 0.0039 0.1656
85 0.0004 0.0018 -0.0031 0.0040 0.1778
86 0.0007 0.0018 -0.0029 0.0042 0.2333
87 0.0003 0.0018 -0.0032 0.0039 0.1674
88 0.0018 0.0019 -0.0020 0.0055 0.5699
89 0.0006 0.0018 -0.0030 0.0041 0.2134
90 0.0005 0.0018 -0.0030 0.0041 0.1999
91 0.0004 0.0018 -0.0032 0.0040 0.1883
92 0.0003 0.0018 -0.0033 0.0038 0.1582
93 0.0010 0.0018 -0.0026 0.0046 0.3058
94 0.0008 0.0018 -0.0027 0.0044 0.2631
95 0.0004 0.0018 -0.0031 0.0040 0.1818
96 0.0004 0.0018 -0.0032 0.0039 0.1673
97 0.0007 0.0018 -0.0029 0.0042 0.2327
98 0.0007 0.0018 -0.0029 0.0042 0.2290
99 0.0004 0.0018 -0.0031 0.0039 0.1761
100 0.0005 0.0018 -0.0031 0.0040 0.1853
101 0.0003 0.0018 -0.0033 0.0038 0.1529
102 0.0012 0.0019 -0.0025 0.0048 0.3662
103 0.0009 0.0018 -0.0027 0.0045 0.2856
104 0.0004 0.0018 -0.0032 0.0039 0.1682
105 0.0009 0.0018 -0.0026 0.0045 0.2905
106 0.0003 0.0018 -0.0032 0.0039 0.1637
107 0.0015 0.0018 -0.0021 0.0050 0.4473
108 0.0012 0.0018 -0.0024 0.0047 0.3519
109 0.0013 0.0018 -0.0023 0.0049 0.4122
110 0.0015 0.0020 -0.0025 0.0054 0.4901
111 0.0009 0.0018 -0.0027 0.0044 0.2783
112 0.0010 0.0018 -0.0026 0.0045 0.2993
113 0.0009 0.0018 -0.0027 0.0044 0.2764
114 0.0003 0.0018 -0.0032 0.0039 0.1607
115 0.0006 0.0018 -0.0030 0.0042 0.2150
116 0.0003 0.0018 -0.0033 0.0038 0.1565
117 0.0009 0.0018 -0.0027 0.0045 0.2880
118 0.0021 0.0018 -0.0016 0.0057 0.6650
119 0.0013 0.0020 -0.0025 0.0052 0.4327
120 0.0006 0.0018 -0.0029 0.0042 0.2154
121 0.0004 0.0018 -0.0032 0.0039 0.1710
122 0.0010 0.0018 -0.0026 0.0045 0.3014
123 0.0015 0.0019 -0.0022 0.0051 0.4681
124 0.0004 0.0018 -0.0031 0.0040 0.1789
125 0.0005 0.0018 -0.0030 0.0041 0.1960
126 0.0003 0.0018 -0.0033 0.0038 0.1527
127 0.0005 0.0018 -0.0030 0.0041 0.1987
128 0.0003 0.0018 -0.0033 0.0038 0.1520
129 0.0001 0.0018 -0.0034 0.0037 0.1343
130 0.0004 0.0018 -0.0031 0.0040 0.1788
131 0.0005 0.0018 -0.0030 0.0041 0.2006
132 0.0005 0.0018 -0.0031 0.0040 0.1937
133 0.0004 0.0018 -0.0031 0.0040 0.1779
134 0.0005 0.0018 -0.0031 0.0041 0.1952
135 0.0008 0.0018 -0.0028 0.0043 0.2481
136 0.0014 0.0018 -0.0023 0.0050 0.4175
137 0.0006 0.0018 -0.0030 0.0041 0.2120
138 0.0004 0.0018 -0.0031 0.0040 0.1820
139 0.0007 0.0018 -0.0029 0.0042 0.2329
140 0.0003 0.0018 -0.0032 0.0039 0.1606
141 0.0004 0.0018 -0.0031 0.0040 0.1812
142 0.0005 0.0018 -0.0031 0.0040 0.1892
143 0.0003 0.0018 -0.0033 0.0038 0.1581
144 0.0003 0.0018 -0.0033 0.0038 0.1530
145 0.0005 0.0018 -0.0031 0.0040 0.1919
146 0.0003 0.0018 -0.0032 0.0039 0.1629
147 0.0003 0.0018 -0.0032 0.0039 0.1629
148 0.0003 0.0018 -0.0032 0.0039 0.1612
149 0.0004 0.0018 -0.0032 0.0039 0.1709
150 0.0009 0.0018 -0.0026 0.0045 0.2870
151 0.0010 0.0018 -0.0026 0.0045 0.2961
152 0.0011 0.0018 -0.0024 0.0047 0.3499
153 0.0003 0.0018 -0.0032 0.0039 0.1639
154 0.0005 0.0018 -0.0031 0.0040 0.1919
155 0.0005 0.0018 -0.0031 0.0040 0.1860
156 0.0005 0.0018 -0.0031 0.0040 0.1913
157 0.0008 0.0018 -0.0028 0.0043 0.2479
158 0.0008 0.0018 -0.0028 0.0043 0.2503
159 0.0009 0.0018 -0.0026 0.0045 0.2932
160 0.0003 0.0018 -0.0032 0.0039 0.1628
161 0.0008 0.0018 -0.0027 0.0044 0.2595
162 0.0005 0.0018 -0.0030 0.0041 0.2020
163 0.0005 0.0018 -0.0031 0.0040 0.1897
164 0.0005 0.0018 -0.0031 0.0040 0.1903
165 0.0009 0.0018 -0.0027 0.0044 0.2739
166 0.0017 0.0018 -0.0019 0.0054 0.5483
167 0.0002 0.0018 -0.0034 0.0037 0.1375
168 0.0002 0.0018 -0.0034 0.0037 0.1375
169 0.0014 0.0018 -0.0022 0.0050 0.4323
170 0.0006 0.0018 -0.0030 0.0042 0.2139
171 0.0006 0.0018 -0.0029 0.0042 0.2238
172 0.0006 0.0018 -0.0029 0.0042 0.2208
173 0.0003 0.0018 -0.0032 0.0039 0.1623
174 0.0004 0.0018 -0.0031 0.0040 0.1845
175 0.0008 0.0018 -0.0028 0.0043 0.2563
176 0.0009 0.0018 -0.0027 0.0044 0.2770
177 0.0006 0.0018 -0.0030 0.0042 0.2254
178 0.0003 0.0018 -0.0032 0.0039 0.1634
179 0.0004 0.0018 -0.0032 0.0039 0.1714
180 0.0005 0.0018 -0.0030 0.0041 0.1955
181 0.0006 0.0018 -0.0030 0.0041 0.2110
182 0.0009 0.0018 -0.0027 0.0045 0.2852
183 0.0009 0.0018 -0.0026 0.0045 0.2895
184 0.0003 0.0018 -0.0033 0.0038 0.1544
185 0.0005 0.0018 -0.0030 0.0041 0.2034
186 0.0014 0.0018 -0.0023 0.0050 0.4163
187 0.0005 0.0018 -0.0030 0.0041 0.2020
188 0.0003 0.0018 -0.0032 0.0039 0.1670
189 0.0003 0.0018 -0.0032 0.0039 0.1611
190 0.0003 0.0018 -0.0033 0.0038 0.1577
191 0.0011 0.0018 -0.0024 0.0047 0.3413
192 0.0008 0.0018 -0.0027 0.0044 0.2691
193 0.0010 0.0018 -0.0026 0.0045 0.2997
194 0.0005 0.0018 -0.0030 0.0041 0.1974
195 0.0017 0.0018 -0.0019 0.0053 0.5337
196 0.0006 0.0018 -0.0029 0.0042 0.2246
197 0.0010 0.0018 -0.0026 0.0046 0.3078
198 0.0015 0.0018 -0.0021 0.0051 0.4728
199 0.0005 0.0018 -0.0030 0.0041 0.2000
200 0.0003 0.0018 -0.0033 0.0038 0.1518
201 0.0004 0.0018 -0.0032 0.0039 0.1755
202 0.0003 0.0018 -0.0033 0.0038 0.1587
203 0.0003 0.0018 -0.0032 0.0039 0.1663
204 0.0003 0.0018 -0.0032 0.0039 0.1659
205 0.0004 0.0018 -0.0032 0.0039 0.1705
206 0.0004 0.0018 -0.0032 0.0039 0.1704
207 0.0005 0.0018 -0.0031 0.0040 0.1934
208 0.0004 0.0018 -0.0031 0.0040 0.1825
209 0.0006 0.0018 -0.0029 0.0042 0.2165
210 0.0003 0.0018 -0.0033 0.0038 0.1515
211 0.0003 0.0018 -0.0032 0.0038 0.1587
212 0.0004 0.0018 -0.0031 0.0040 0.1862
213 0.0004 0.0018 -0.0032 0.0039 0.1700
214 0.0004 0.0018 -0.0031 0.0040 0.1790
215 0.0003 0.0018 -0.0032 0.0039 0.1620
216 0.0006 0.0018 -0.0030 0.0041 0.2099
217 0.0005 0.0018 -0.0031 0.0040 0.1933
218 0.0005 0.0018 -0.0031 0.0040 0.1926
219 0.0006 0.0018 -0.0030 0.0041 0.2068
220 0.0006 0.0018 -0.0030 0.0041 0.2070
221 0.0002 0.0018 -0.0033 0.0038 0.1449
222 0.0004 0.0018 -0.0031 0.0040 0.1771
223 0.0002 0.0018 -0.0033 0.0038 0.1487
224 0.0006 0.0018 -0.0029 0.0042 0.2179
225 0.0003 0.0018 -0.0033 0.0038 0.1544
226 0.0023 0.0018 -0.0013 0.0059 0.7668
227 0.0004 0.0018 -0.0032 0.0039 0.1737
228 0.0006 0.0018 -0.0030 0.0041 0.2089
229 0.0009 0.0018 -0.0027 0.0044 0.2796
230 0.0005 0.0018 -0.0031 0.0040 0.1871
231 0.0002 0.0018 -0.0033 0.0038 0.1455
232 0.0004 0.0018 -0.0032 0.0039 0.1730
233 0.0013 0.0018 -0.0023 0.0048 0.3862
234 0.0003 0.0018 -0.0033 0.0038 0.1575
235 0.0003 0.0018 -0.0032 0.0039 0.1608
236 0.0003 0.0018 -0.0033 0.0038 0.1527
237 0.0004 0.0018 -0.0032 0.0039 0.1761
238 0.0006 0.0018 -0.0030 0.0041 0.2123
239 0.0007 0.0018 -0.0028 0.0043 0.2423
240 0.0017 0.0018 -0.0018 0.0053 0.5432
241 0.0013 0.0018 -0.0023 0.0048 0.3886
242 0.0003 0.0018 -0.0033 0.0038 0.1580
243 0.0017 0.0018 -0.0019 0.0053 0.5307
244 0.0003 0.0018 -0.0032 0.0039 0.1670
245 0.0006 0.0018 -0.0029 0.0042 0.2238
246 0.0013 0.0018 -0.0023 0.0048 0.3859
247 0.0011 0.0018 -0.0025 0.0046 0.3311
248 0.0005 0.0018 -0.0030 0.0041 0.2002
249 0.0003 0.0018 -0.0033 0.0038 0.1542
250 0.0003 0.0018 -0.0033 0.0038 0.1552
251 0.0009 0.0018 -0.0027 0.0045 0.2929
252 0.0007 0.0018 -0.0028 0.0043 0.2366
253 0.0004 0.0018 -0.0031 0.0040 0.1817
254 0.0011 0.0018 -0.0025 0.0046 0.3281
255 0.0006 0.0018 -0.0029 0.0042 0.2223
256 0.0006 0.0018 -0.0029 0.0042 0.2208
257 0.0004 0.0018 -0.0031 0.0040 0.1771
258 0.0005 0.0018 -0.0030 0.0041 0.2031
259 0.0005 0.0018 -0.0031 0.0040 0.1864
260 0.0003 0.0018 -0.0032 0.0039 0.1642
261 0.0014 0.0018 -0.0022 0.0050 0.4395
262 0.0007 0.0018 -0.0028 0.0043 0.2415
263 0.0005 0.0018 -0.0030 0.0041 0.2039
264 0.0003 0.0018 -0.0033 0.0038 0.1535
265 0.0004 0.0018 -0.0032 0.0039 0.1674
266 0.0011 0.0018 -0.0024 0.0047 0.3404
267 0.0004 0.0018 -0.0031 0.0040 0.1849
268 0.0004 0.0018 -0.0031 0.0039 0.1761
269 0.0005 0.0018 -0.0030 0.0041 0.1991
270 0.0005 0.0018 -0.0030 0.0041 0.1961
271 0.0013 0.0018 -0.0023 0.0048 0.3843
272 0.0006 0.0018 -0.0029 0.0042 0.2197
273 0.0003 0.0018 -0.0032 0.0039 0.1632
274 0.0002 0.0018 -0.0033 0.0038 0.1487
275 0.0010 0.0018 -0.0025 0.0046 0.3092
276 0.0008 0.0018 -0.0027 0.0044 0.2655
277 0.0011 0.0018 -0.0024 0.0047 0.3461
278 0.0011 0.0018 -0.0024 0.0047 0.3371
279 0.0009 0.0018 -0.0026 0.0045 0.2829
280 0.0007 0.0018 -0.0029 0.0042 0.2254
281 0.0014 0.0018 -0.0022 0.0050 0.4249
282 0.0002 0.0018 -0.0033 0.0038 0.1493
283 0.0014 0.0018 -0.0021 0.0050 0.4343
284 0.0004 0.0018 -0.0031 0.0040 0.1779
285 0.0006 0.0018 -0.0029 0.0042 0.2253
286 0.0003 0.0018 -0.0033 0.0038 0.1558
287 0.0030 0.0020 -0.0010 0.0070 0.9402
288 0.0006 0.0018 -0.0030 0.0041 0.2047
289 0.0006 0.0018 -0.0029 0.0042 0.2190
290 0.0004 0.0018 -0.0031 0.0040 0.1824
291 0.0014 0.0018 -0.0022 0.0049 0.4165
292 0.0005 0.0018 -0.0031 0.0040 0.1867
293 0.0009 0.0019 -0.0028 0.0045 0.2867
294 0.0009 0.0018 -0.0026 0.0045 0.2945
295 0.0011 0.0018 -0.0024 0.0047 0.3434
296 0.0004 0.0018 -0.0032 0.0039 0.1690
297 0.0004 0.0018 -0.0032 0.0039 0.1747
298 0.0006 0.0018 -0.0030 0.0041 0.2059
299 0.0016 0.0018 -0.0020 0.0052 0.4863
300 0.0012 0.0018 -0.0023 0.0048 0.3784
301 0.0014 0.0019 -0.0024 0.0051 0.4446
302 0.0004 0.0018 -0.0032 0.0039 0.1713
303 0.0012 0.0018 -0.0024 0.0048 0.3588
304 0.0004 0.0018 -0.0032 0.0039 0.1716
305 0.0004 0.0018 -0.0031 0.0040 0.1832
306 0.0006 0.0018 -0.0029 0.0042 0.2225
307 0.0011 0.0019 -0.0026 0.0049 0.3700
308 0.0004 0.0018 -0.0032 0.0039 0.1758
309 0.0007 0.0018 -0.0029 0.0042 0.2344
310 0.0004 0.0018 -0.0031 0.0040 0.1800
311 0.0009 0.0018 -0.0027 0.0045 0.2919
312 0.0003 0.0018 -0.0032 0.0039 0.1668
313 0.0015 0.0018 -0.0021 0.0050 0.4492
314 0.0007 0.0018 -0.0028 0.0043 0.2417
315 0.0011 0.0018 -0.0025 0.0046 0.3290
316 0.0004 0.0018 -0.0031 0.0040 0.1834
317 0.0027 0.0018 -0.0009 0.0062 0.9172
318 0.0015 0.0018 -0.0021 0.0051 0.4645
319 0.0003 0.0018 -0.0032 0.0039 0.1602
320 0.0007 0.0018 -0.0029 0.0042 0.2264
321 0.0016 0.0018 -0.0020 0.0052 0.5011
322 0.0004 0.0018 -0.0031 0.0040 0.1817
323 0.0003 0.0018 -0.0033 0.0038 0.1575
324 0.0003 0.0018 -0.0032 0.0039 0.1644
325 0.0006 0.0018 -0.0030 0.0041 0.2097
326 0.0024 0.0018 -0.0012 0.0059 0.7868
327 0.0004 0.0018 -0.0032 0.0039 0.1739
328 0.0003 0.0018 -0.0033 0.0038 0.1534
329 0.0030 0.0018 -0.0006 0.0066 0.9254
330 0.0031 0.0018 -0.0005 0.0067 0.8773
331 0.0003 0.0018 -0.0032 0.0039 0.1632
332 0.0006 0.0018 -0.0029 0.0042 0.2214
333 0.0066 0.0019 0.0029 0.0103 0.0479 **
334 0.0004 0.0018 -0.0032 0.0039 0.1684
335 0.0009 0.0018 -0.0026 0.0045 0.2949
336 0.0005 0.0018 -0.0030 0.0041 0.2005
337 0.0009 0.0018 -0.0026 0.0045 0.2934
338 0.0013 0.0018 -0.0023 0.0049 0.4040
339 0.0005 0.0018 -0.0031 0.0040 0.1916
340 0.0009 0.0018 -0.0027 0.0045 0.2811
341 0.0013 0.0018 -0.0023 0.0049 0.3950
342 0.0003 0.0018 -0.0032 0.0039 0.1609
343 0.0021 0.0018 -0.0015 0.0057 0.6808
344 0.0006 0.0018 -0.0030 0.0041 0.2057
345 0.0015 0.0018 -0.0021 0.0050 0.4461
346 0.0010 0.0018 -0.0026 0.0046 0.3231
347 0.0010 0.0018 -0.0026 0.0046 0.3080
348 0.0004 0.0018 -0.0032 0.0039 0.1690
349 0.0005 0.0018 -0.0030 0.0041 0.2018
350 0.0031 0.0018 -0.0005 0.0067 0.8894
351 0.0003 0.0018 -0.0033 0.0038 0.1516
352 0.0004 0.0018 -0.0031 0.0040 0.1848
353 0.0009 0.0018 -0.0027 0.0044 0.2759
354 0.0012 0.0018 -0.0023 0.0048 0.3709
355 0.0007 0.0018 -0.0029 0.0042 0.2253
356 0.0005 0.0018 -0.0031 0.0040 0.1876
357 0.0010 0.0018 -0.0026 0.0046 0.3036
358 0.0005 0.0018 -0.0030 0.0041 0.2015
359 0.0005 0.0018 -0.0030 0.0041 0.2013
360 0.0005 0.0018 -0.0030 0.0041 0.1949
361 0.0007 0.0018 -0.0029 0.0042 0.2280
362 0.0017 0.0019 -0.0019 0.0054 0.5461
363 0.0005 0.0018 -0.0031 0.0040 0.1913
364 0.0005 0.0018 -0.0030 0.0041 0.2036
365 0.0019 0.0018 -0.0017 0.0055 0.6095
366 0.0041 0.0019 0.0004 0.0079 0.4998
367 0.0009 0.0018 -0.0027 0.0044 0.2808
368 0.0010 0.0018 -0.0026 0.0045 0.2972
369 0.0011 0.0018 -0.0024 0.0047 0.3415
370 0.0004 0.0018 -0.0031 0.0040 0.1813
371 0.0005 0.0018 -0.0031 0.0040 0.1868
372 0.0013 0.0018 -0.0023 0.0049 0.3953
373 0.0004 0.0018 -0.0032 0.0039 0.1694
374 0.0014 0.0018 -0.0022 0.0049 0.4195
375 0.0012 0.0018 -0.0024 0.0048 0.3587
376 0.0010 0.0018 -0.0025 0.0046 0.3191
377 0.0009 0.0018 -0.0026 0.0045 0.2893
378 0.0004 0.0018 -0.0032 0.0039 0.1731
379 0.0009 0.0019 -0.0028 0.0045 0.2905
380 0.0007 0.0018 -0.0029 0.0042 0.2341
381 0.0003 0.0018 -0.0032 0.0039 0.1656
382 0.0006 0.0018 -0.0030 0.0042 0.2135
383 0.0007 0.0018 -0.0029 0.0042 0.2308
384 0.0004 0.0018 -0.0032 0.0039 0.1700
385 0.0004 0.0018 -0.0032 0.0039 0.1752
386 0.0020 0.0018 -0.0016 0.0056 0.6429
387 0.0007 0.0018 -0.0029 0.0042 0.2316
388 0.0003 0.0018 -0.0033 0.0038 0.1581
389 0.0009 0.0018 -0.0027 0.0044 0.2733
390 0.0003 0.0018 -0.0032 0.0038 0.1591
391 0.0013 0.0018 -0.0023 0.0048 0.3856
392 0.0010 0.0018 -0.0026 0.0045 0.3026
393 0.0009 0.0018 -0.0027 0.0045 0.2957
394 0.0007 0.0018 -0.0028 0.0043 0.2455
395 0.0004 0.0018 -0.0032 0.0039 0.1710
396 0.0007 0.0018 -0.0029 0.0043 0.2371
397 0.0005 0.0018 -0.0030 0.0041 0.1945
398 0.0005 0.0018 -0.0031 0.0040 0.1894
399 0.0004 0.0018 -0.0031 0.0040 0.1820
400 0.0003 0.0018 -0.0032 0.0039 0.1633
401 0.0008 0.0018 -0.0028 0.0043 0.2504
402 0.0003 0.0018 -0.0032 0.0039 0.1630
403 0.0004 0.0018 -0.0032 0.0039 0.1740
404 0.0011 0.0018 -0.0025 0.0046 0.3286
405 0.0004 0.0018 -0.0032 0.0039 0.1715
406 0.0008 0.0018 -0.0028 0.0044 0.2595
407 0.0006 0.0018 -0.0030 0.0041 0.2086
408 0.0003 0.0018 -0.0032 0.0039 0.1610
409 0.0010 0.0018 -0.0026 0.0046 0.3083
410 0.0005 0.0018 -0.0030 0.0041 0.2030
411 0.0004 0.0018 -0.0031 0.0040 0.1840
412 0.0004 0.0018 -0.0031 0.0039 0.1763
413 0.0005 0.0018 -0.0031 0.0040 0.1939
414 0.0004 0.0018 -0.0032 0.0039 0.1749
415 0.0006 0.0018 -0.0029 0.0042 0.2203
416 0.0005 0.0018 -0.0031 0.0040 0.1934
417 0.0002 0.0018 -0.0033 0.0038 0.1450
418 0.0006 0.0018 -0.0030 0.0041 0.2130
419 0.0009 0.0018 -0.0026 0.0045 0.2864
420 0.0004 0.0018 -0.0031 0.0040 0.1787
421 0.0003 0.0018 -0.0032 0.0039 0.1595
422 0.0007 0.0018 -0.0029 0.0042 0.2327
423 0.0006 0.0018 -0.0030 0.0041 0.2051
424 0.0010 0.0018 -0.0026 0.0046 0.3065
425 0.0009 0.0018 -0.0027 0.0044 0.2723
426 0.0012 0.0018 -0.0024 0.0047 0.3511
427 0.0004 0.0018 -0.0031 0.0039 0.1761
428 0.0007 0.0018 -0.0029 0.0042 0.2301
429 0.0004 0.0018 -0.0031 0.0040 0.1784
430 0.0006 0.0018 -0.0029 0.0042 0.2147
431 0.0005 0.0018 -0.0030 0.0041 0.2037
432 0.0003 0.0018 -0.0032 0.0039 0.1658
433 0.0004 0.0018 -0.0031 0.0040 0.1781
434 0.0008 0.0018 -0.0028 0.0043 0.2571
435 0.0003 0.0018 -0.0033 0.0038 0.1542
436 0.0004 0.0018 -0.0032 0.0039 0.1750
437 0.0019 0.0018 -0.0017 0.0055 0.6077
438 0.0005 0.0018 -0.0031 0.0040 0.1892
439 0.0002 0.0018 -0.0033 0.0038 0.1459
440 0.0017 0.0018 -0.0019 0.0053 0.5277
441 0.0008 0.0018 -0.0027 0.0044 0.2696
442 0.0003 0.0018 -0.0032 0.0039 0.1645
443 0.0005 0.0018 -0.0031 0.0040 0.1888
444 0.0002 0.0018 -0.0033 0.0038 0.1466
445 0.0006 0.0018 -0.0030 0.0041 0.2043
446 0.0002 0.0018 -0.0033 0.0038 0.1450
447 0.0009 0.0018 -0.0027 0.0045 0.2897
448 0.0003 0.0018 -0.0033 0.0038 0.1574
449 0.0004 0.0018 -0.0031 0.0040 0.1818
450 0.0004 0.0018 -0.0031 0.0040 0.1820
451 0.0007 0.0018 -0.0029 0.0042 0.2332
452 0.0012 0.0018 -0.0024 0.0048 0.3636
453 0.0005 0.0018 -0.0030 0.0041 0.2004
454 0.0020 0.0018 -0.0016 0.0056 0.6438
455 0.0003 0.0018 -0.0033 0.0038 0.1517
456 0.0007 0.0018 -0.0029 0.0043 0.2406
457 0.0006 0.0018 -0.0030 0.0042 0.2172
458 0.0005 0.0018 -0.0031 0.0040 0.1858
459 0.0006 0.0018 -0.0030 0.0041 0.2111
460 0.0005 0.0018 -0.0030 0.0041 0.2034
461 0.0003 0.0018 -0.0032 0.0039 0.1656
462 0.0005 0.0018 -0.0031 0.0040 0.1904
463 0.0034 0.0020 -0.0006 0.0073 0.7936
464 0.0010 0.0018 -0.0025 0.0046 0.3141
465 0.0008 0.0018 -0.0028 0.0043 0.2520
466 0.0007 0.0018 -0.0029 0.0042 0.2278
467 0.0018 0.0018 -0.0019 0.0054 0.5525
468 0.0005 0.0018 -0.0030 0.0041 0.1950
469 0.0007 0.0018 -0.0029 0.0042 0.2313
470 0.0005 0.0018 -0.0030 0.0041 0.2019
471 0.0009 0.0019 -0.0028 0.0045 0.2891
472 0.0016 0.0018 -0.0020 0.0052 0.4863
473 0.0028 0.0018 -0.0008 0.0064 0.9924
474 0.0006 0.0018 -0.0030 0.0041 0.2056
475 0.0008 0.0018 -0.0027 0.0044 0.2628
476 0.0003 0.0018 -0.0033 0.0038 0.1573
477 0.0003 0.0018 -0.0033 0.0038 0.1578
478 0.0007 0.0018 -0.0028 0.0043 0.2378
479 0.0008 0.0018 -0.0028 0.0043 0.2482
480 0.0004 0.0018 -0.0032 0.0039 0.1686
481 0.0003 0.0018 -0.0032 0.0039 0.1638
482 0.0005 0.0018 -0.0031 0.0040 0.1858
483 0.0005 0.0018 -0.0030 0.0041 0.1958
484 0.0004 0.0018 -0.0031 0.0040 0.1819
485 0.0008 0.0018 -0.0028 0.0043 0.2498
486 0.0007 0.0019 -0.0029 0.0044 0.2547
487 0.0010 0.0018 -0.0026 0.0046 0.3173
488 0.0016 0.0018 -0.0020 0.0052 0.4880
489 0.0007 0.0018 -0.0028 0.0043 0.2526
490 0.0005 0.0018 -0.0030 0.0041 0.1988
491 0.0009 0.0018 -0.0028 0.0045 0.2808
492 0.0005 0.0018 -0.0030 0.0041 0.2043
493 0.0004 0.0018 -0.0032 0.0039 0.1736
494 0.0033 0.0018 -0.0003 0.0069 0.8013
495 0.0006 0.0018 -0.0030 0.0041 0.2123
496 0.0005 0.0018 -0.0030 0.0041 0.1968
497 0.0010 0.0018 -0.0026 0.0046 0.3201
498 0.0009 0.0019 -0.0027 0.0046 0.3056
499 0.0005 0.0018 -0.0031 0.0040 0.1879
500 0.0004 0.0018 -0.0031 0.0040 0.1850
501 0.0007 0.0018 -0.0029 0.0043 0.2364
502 0.0003 0.0018 -0.0032 0.0039 0.1619
503 0.0004 0.0018 -0.0032 0.0039 0.1729
504 0.0003 0.0018 -0.0032 0.0039 0.1674
505 0.0009 0.0018 -0.0026 0.0045 0.2928
506 0.0012 0.0018 -0.0024 0.0048 0.3619
507 0.0003 0.0018 -0.0032 0.0039 0.1634
508 0.0007 0.0018 -0.0029 0.0043 0.2487
509 0.0007 0.0018 -0.0028 0.0043 0.2372
510 0.0009 0.0018 -0.0027 0.0044 0.2743
511 0.0003 0.0018 -0.0033 0.0038 0.1519
512 0.0003 0.0018 -0.0032 0.0039 0.1670
513 0.0007 0.0018 -0.0028 0.0043 0.2449
514 0.0061 0.0019 0.0023 0.0098 0.0975 *
515 0.0003 0.0018 -0.0032 0.0039 0.1651
516 0.0005 0.0018 -0.0030 0.0041 0.1961
517 0.0023 0.0018 -0.0013 0.0059 0.7682
518 0.0004 0.0018 -0.0032 0.0039 0.1715
519 0.0014 0.0018 -0.0021 0.0050 0.4388
520 0.0007 0.0018 -0.0028 0.0043 0.2431
521 0.0004 0.0018 -0.0032 0.0039 0.1710
522 0.0009 0.0018 -0.0027 0.0044 0.2800
523 0.0005 0.0018 -0.0031 0.0040 0.1882
524 0.0009 0.0018 -0.0026 0.0045 0.2834
525 0.0008 0.0018 -0.0027 0.0044 0.2647
526 0.0011 0.0018 -0.0024 0.0047 0.3359
527 0.0008 0.0018 -0.0027 0.0044 0.2624
528 0.0003 0.0018 -0.0032 0.0038 0.1587
529 0.0004 0.0018 -0.0032 0.0039 0.1751
530 0.0004 0.0018 -0.0032 0.0039 0.1735
531 0.0011 0.0018 -0.0024 0.0047 0.3398
532 0.0005 0.0018 -0.0030 0.0041 0.2027
533 0.0007 0.0018 -0.0029 0.0042 0.2336
534 0.0004 0.0018 -0.0031 0.0040 0.1792
535 0.0005 0.0018 -0.0031 0.0041 0.1951
536 0.0008 0.0018 -0.0027 0.0044 0.2711
537 0.0004 0.0018 -0.0031 0.0040 0.1853
538 0.0005 0.0018 -0.0030 0.0041 0.2015
539 0.0009 0.0018 -0.0027 0.0045 0.2831
540 0.0007 0.0018 -0.0028 0.0043 0.2404
541 0.0003 0.0018 -0.0033 0.0038 0.1572
542 0.0004 0.0018 -0.0032 0.0039 0.1738
543 0.0009 0.0018 -0.0027 0.0045 0.2822
544 0.0009 0.0018 -0.0027 0.0044 0.2697
545 0.0002 0.0018 -0.0033 0.0038 0.1473
546 0.0004 0.0018 -0.0031 0.0040 0.1816
547 0.0006 0.0018 -0.0029 0.0042 0.2171
548 0.0025 0.0018 -0.0011 0.0062 0.8693
549 0.0006 0.0018 -0.0029 0.0042 0.2254
550 0.0031 0.0018 -0.0005 0.0067 0.8719
551 0.0017 0.0019 -0.0020 0.0054 0.5509
552 0.0008 0.0018 -0.0028 0.0043 0.2518
553 0.0003 0.0018 -0.0032 0.0039 0.1596
554 0.0003 0.0018 -0.0032 0.0039 0.1610
555 0.0010 0.0018 -0.0025 0.0046 0.3190
556 0.0005 0.0018 -0.0031 0.0040 0.1882
557 0.0003 0.0018 -0.0033 0.0038 0.1540
558 0.0020 0.0018 -0.0016 0.0055 0.6293
559 0.0003 0.0018 -0.0032 0.0039 0.1651
560 0.0005 0.0018 -0.0031 0.0040 0.1883
561 0.0033 0.0019 -0.0004 0.0069 0.8227
562 0.0021 0.0018 -0.0015 0.0057 0.6743
563 0.0009 0.0018 -0.0027 0.0044 0.2741
564 0.0010 0.0019 -0.0027 0.0046 0.3187
565 0.0058 0.0019 0.0022 0.0095 0.1115
566 0.0004 0.0018 -0.0032 0.0039 0.1726
567 0.0003 0.0018 -0.0032 0.0039 0.1658
568 0.0004 0.0018 -0.0032 0.0039 0.1731
569 0.0006 0.0018 -0.0030 0.0041 0.2048
570 0.0014 0.0018 -0.0022 0.0050 0.4260
571 0.0005 0.0018 -0.0031 0.0040 0.1938
572 0.0003 0.0018 -0.0033 0.0038 0.1521
573 0.0005 0.0018 -0.0030 0.0041 0.2034
574 0.0007 0.0018 -0.0029 0.0042 0.2313
575 0.0002 0.0018 -0.0033 0.0038 0.1456
576 0.0008 0.0018 -0.0028 0.0044 0.2601
577 0.0008 0.0018 -0.0027 0.0043 0.2577
578 0.0004 0.0018 -0.0031 0.0040 0.1805
579 0.0006 0.0018 -0.0029 0.0042 0.2249
580 0.0009 0.0018 -0.0027 0.0044 0.2718
581 0.0017 0.0019 -0.0020 0.0054 0.5502
582 0.0014 0.0018 -0.0022 0.0050 0.4293
583 0.0006 0.0018 -0.0030 0.0041 0.2068
584 0.0005 0.0018 -0.0030 0.0041 0.2055
585 0.0012 0.0019 -0.0025 0.0048 0.3696
586 0.0009 0.0019 -0.0028 0.0045 0.2862
587 0.0005 0.0018 -0.0030 0.0040 0.1941
588 0.0007 0.0018 -0.0028 0.0043 0.2434
589 0.0007 0.0018 -0.0029 0.0042 0.2336
590 0.0012 0.0018 -0.0024 0.0047 0.3591
591 0.0004 0.0018 -0.0032 0.0039 0.1725
592 0.0005 0.0018 -0.0030 0.0041 0.1953
593 0.0004 0.0018 -0.0032 0.0039 0.1704
594 0.0005 0.0018 -0.0030 0.0041 0.1990
595 0.0008 0.0018 -0.0028 0.0044 0.2670
596 0.0004 0.0018 -0.0032 0.0039 0.1721
597 0.0003 0.0018 -0.0033 0.0038 0.1540
598 0.0005 0.0018 -0.0031 0.0040 0.1891
599 0.0003 0.0018 -0.0032 0.0039 0.1645
600 0.0005 0.0018 -0.0030 0.0041 0.2033
601 0.0005 0.0018 -0.0030 0.0041 0.2010
602 0.0002 0.0018 -0.0034 0.0037 0.1412
603 0.0006 0.0018 -0.0029 0.0042 0.2211
604 0.0008 0.0019 -0.0028 0.0044 0.2671
605 0.0007 0.0018 -0.0028 0.0043 0.2426
606 0.0004 0.0018 -0.0032 0.0039 0.1725
607 0.0003 0.0018 -0.0033 0.0038 0.1572
608 0.0006 0.0018 -0.0029 0.0042 0.2190
609 0.0003 0.0018 -0.0032 0.0039 0.1629
610 0.0002 0.0018 -0.0033 0.0038 0.1497
611 0.0005 0.0018 -0.0030 0.0041 0.2010
612 0.0006 0.0018 -0.0030 0.0041 0.2043
613 0.0006 0.0018 -0.0029 0.0042 0.2189
614 0.0024 0.0021 -0.0017 0.0065 0.8319
615 0.0007 0.0018 -0.0028 0.0043 0.2401
616 0.0007 0.0018 -0.0028 0.0043 0.2409
617 0.0004 0.0018 -0.0032 0.0039 0.1726
618 0.0006 0.0018 -0.0030 0.0041 0.2138
619 0.0002 0.0018 -0.0034 0.0037 0.1402
620 0.0010 0.0018 -0.0026 0.0045 0.2990
621 0.0003 0.0018 -0.0032 0.0039 0.1669
622 0.0005 0.0018 -0.0030 0.0041 0.1946
623 0.0003 0.0018 -0.0033 0.0038 0.1539
624 0.0007 0.0018 -0.0028 0.0043 0.2507
625 0.0002 0.0018 -0.0033 0.0038 0.1505
626 0.0008 0.0018 -0.0027 0.0044 0.2627
627 0.0004 0.0018 -0.0031 0.0040 0.1841
628 0.0005 0.0018 -0.0030 0.0041 0.2039
629 0.0003 0.0018 -0.0032 0.0039 0.1650
630 0.0031 0.0018 -0.0005 0.0067 0.8746
631 0.0008 0.0018 -0.0027 0.0044 0.2623
632 0.0003 0.0018 -0.0032 0.0039 0.1602
633 0.0005 0.0018 -0.0031 0.0041 0.1947
634 0.0022 0.0018 -0.0013 0.0058 0.7401
635 0.0003 0.0018 -0.0033 0.0038 0.1565
636 0.0006 0.0018 -0.0030 0.0041 0.2091
637 0.0006 0.0018 -0.0030 0.0041 0.2121
638 0.0004 0.0018 -0.0031 0.0040 0.1826
639 0.0007 0.0018 -0.0029 0.0042 0.2256
640 0.0005 0.0018 -0.0030 0.0041 0.1988
641 0.0003 0.0018 -0.0033 0.0038 0.1515
642 0.0006 0.0018 -0.0030 0.0041 0.2105
643 0.0003 0.0018 -0.0032 0.0039 0.1667
644 0.0007 0.0018 -0.0028 0.0043 0.2367
645 0.0003 0.0018 -0.0033 0.0038 0.1575
646 0.0005 0.0018 -0.0031 0.0040 0.1877
647 0.0010 0.0018 -0.0026 0.0045 0.3024
648 0.0014 0.0018 -0.0022 0.0050 0.4248
649 0.0003 0.0018 -0.0032 0.0039 0.1612
650 0.0003 0.0018 -0.0033 0.0038 0.1550
651 0.0007 0.0018 -0.0028 0.0043 0.2399
652 0.0003 0.0018 -0.0033 0.0038 0.1550
653 0.0005 0.0018 -0.0030 0.0041 0.1965
654 0.0004 0.0018 -0.0032 0.0039 0.1719
655 0.0008 0.0018 -0.0027 0.0044 0.2614
656 0.0005 0.0018 -0.0031 0.0040 0.1873
657 0.0009 0.0018 -0.0027 0.0044 0.2731
658 0.0011 0.0018 -0.0025 0.0046 0.3261
659 0.0009 0.0018 -0.0027 0.0045 0.2941
660 0.0008 0.0018 -0.0027 0.0044 0.2676
661 0.0004 0.0018 -0.0032 0.0039 0.1697
662 0.0010 0.0018 -0.0026 0.0045 0.3049
663 0.0004 0.0018 -0.0032 0.0039 0.1699
664 0.0005 0.0018 -0.0030 0.0041 0.2026
665 0.0010 0.0018 -0.0026 0.0046 0.3192
666 0.0007 0.0018 -0.0029 0.0043 0.2357
667 0.0004 0.0018 -0.0031 0.0040 0.1848
668 0.0006 0.0018 -0.0029 0.0042 0.2226
669 0.0003 0.0018 -0.0033 0.0038 0.1566
670 0.0004 0.0018 -0.0032 0.0039 0.1733
671 0.0003 0.0018 -0.0033 0.0038 0.1516
672 0.0007 0.0018 -0.0029 0.0042 0.2327
673 0.0015 0.0018 -0.0021 0.0051 0.4587
674 0.0008 0.0018 -0.0027 0.0044 0.2606
675 0.0022 0.0018 -0.0014 0.0057 0.7068
676 0.0006 0.0018 -0.0030 0.0041 0.2048
677 0.0012 0.0018 -0.0024 0.0048 0.3630
678 0.0012 0.0019 -0.0025 0.0048 0.3696
679 0.0017 0.0018 -0.0019 0.0052 0.5133
680 0.0008 0.0018 -0.0027 0.0044 0.2653
681 0.0007 0.0018 -0.0029 0.0042 0.2281
682 0.0008 0.0018 -0.0027 0.0044 0.2633
683 0.0009 0.0018 -0.0027 0.0044 0.2785
684 0.0012 0.0018 -0.0024 0.0047 0.3550
685 0.0003 0.0018 -0.0033 0.0038 0.1573
686 0.0002 0.0018 -0.0033 0.0038 0.1435
687 0.0002 0.0018 -0.0034 0.0037 0.1424
688 0.0005 0.0018 -0.0031 0.0040 0.1906
689 0.0005 0.0018 -0.0030 0.0041 0.1959
690 0.0003 0.0018 -0.0033 0.0038 0.1526
691 0.0005 0.0018 -0.0030 0.0041 0.1981
692 0.0005 0.0018 -0.0031 0.0040 0.1935
693 0.0005 0.0018 -0.0031 0.0040 0.1905
694 0.0004 0.0018 -0.0032 0.0039 0.1696
695 0.0008 0.0018 -0.0027 0.0044 0.2669
696 0.0012 0.0018 -0.0024 0.0047 0.3561
697 0.0011 0.0018 -0.0025 0.0046 0.3244
698 0.0009 0.0018 -0.0027 0.0044 0.2727
699 0.0003 0.0018 -0.0032 0.0039 0.1621
700 0.0004 0.0018 -0.0032 0.0039 0.1721
701 0.0004 0.0018 -0.0032 0.0039 0.1733
702 0.0003 0.0018 -0.0032 0.0039 0.1621
703 0.0008 0.0018 -0.0028 0.0043 0.2513
704 0.0008 0.0018 -0.0028 0.0043 0.2527
705 0.0004 0.0018 -0.0032 0.0039 0.1687
706 0.0004 0.0018 -0.0032 0.0039 0.1712
707 0.0003 0.0018 -0.0033 0.0038 0.1518
708 0.0004 0.0018 -0.0031 0.0040 0.1769
709 0.0013 0.0018 -0.0022 0.0049 0.3996
710 0.0010 0.0018 -0.0025 0.0046 0.3151
711 0.0010 0.0018 -0.0025 0.0046 0.3210
712 0.0018 0.0018 -0.0018 0.0054 0.5552
713 0.0005 0.0018 -0.0030 0.0041 0.2029
714 0.0004 0.0018 -0.0031 0.0040 0.1770
715 0.0002 0.0018 -0.0033 0.0038 0.1459
716 0.0018 0.0018 -0.0018 0.0054 0.5676
717 0.0008 0.0018 -0.0028 0.0043 0.2495
718 0.0018 0.0018 -0.0018 0.0054 0.5646
719 0.0002 0.0018 -0.0034 0.0037 0.1412
720 0.0002 0.0018 -0.0034 0.0037 0.1384
721 0.0006 0.0018 -0.0030 0.0042 0.2188
722 0.0012 0.0019 -0.0024 0.0049 0.3893
723 0.0012 0.0019 -0.0024 0.0048 0.3691
724 0.0012 0.0019 -0.0026 0.0049 0.3755
725 0.0011 0.0018 -0.0025 0.0047 0.3360
726 0.0015 0.0018 -0.0021 0.0051 0.4757
727 0.0005 0.0018 -0.0031 0.0040 0.1885
728 0.0008 0.0018 -0.0027 0.0044 0.2705
729 0.0018 0.0018 -0.0017 0.0054 0.5781
730 0.0009 0.0018 -0.0027 0.0045 0.2829
731 0.0015 0.0018 -0.0021 0.0050 0.4478
732 0.0007 0.0018 -0.0028 0.0043 0.2397
733 0.0009 0.0018 -0.0027 0.0044 0.2775
734 0.0016 0.0018 -0.0020 0.0052 0.4885
735 0.0023 0.0018 -0.0013 0.0059 0.7542
736 0.0039 0.0019 0.0003 0.0076 0.5551
737 0.0006 0.0018 -0.0030 0.0041 0.2082
738 0.0004 0.0018 -0.0031 0.0040 0.1847
739 0.0006 0.0018 -0.0030 0.0041 0.2118
740 0.0005 0.0018 -0.0030 0.0041 0.2007
741 0.0004 0.0018 -0.0032 0.0039 0.1711
742 0.0014 0.0018 -0.0021 0.0050 0.4332
743 0.0023 0.0019 -0.0013 0.0059 0.7629
744 0.0009 0.0018 -0.0026 0.0045 0.2835
745 0.0027 0.0019 -0.0009 0.0063 0.9308
746 0.0007 0.0018 -0.0028 0.0043 0.2367
747 0.0021 0.0018 -0.0015 0.0057 0.6885
748 0.0007 0.0018 -0.0029 0.0042 0.2265
749 0.0048 0.0019 0.0011 0.0085 0.3089
750 0.0010 0.0018 -0.0025 0.0046 0.3193
751 0.0014 0.0018 -0.0021 0.0050 0.4406
752 0.0019 0.0018 -0.0016 0.0055 0.6191
753 0.0007 0.0018 -0.0029 0.0042 0.2304
754 0.0009 0.0018 -0.0027 0.0044 0.2722
755 0.0004 0.0018 -0.0032 0.0039 0.1684
756 0.0014 0.0018 -0.0021 0.0050 0.4347
757 0.0006 0.0018 -0.0029 0.0042 0.2153
758 0.0008 0.0018 -0.0028 0.0043 0.2502
759 0.0003 0.0018 -0.0033 0.0038 0.1564
760 0.0011 0.0018 -0.0025 0.0047 0.3366
761 0.0003 0.0018 -0.0033 0.0038 0.1558
762 0.0010 0.0018 -0.0025 0.0046 0.3086
763 0.0015 0.0018 -0.0021 0.0051 0.4607
764 0.0021 0.0019 -0.0016 0.0058 0.6905
765 0.0007 0.0018 -0.0028 0.0043 0.2425
766 0.0004 0.0018 -0.0031 0.0040 0.1844
767 0.0022 0.0018 -0.0014 0.0057 0.7082
768 0.0026 0.0019 -0.0011 0.0064 0.9079
769 0.0008 0.0018 -0.0027 0.0044 0.2698
770 0.0013 0.0018 -0.0023 0.0049 0.4000
771 0.0004 0.0018 -0.0031 0.0040 0.1841
772 0.0009 0.0018 -0.0027 0.0045 0.2830
773 0.0008 0.0018 -0.0028 0.0043 0.2506
774 0.0013 0.0018 -0.0022 0.0049 0.4072
775 0.0018 0.0018 -0.0018 0.0054 0.5749
776 0.0008 0.0018 -0.0028 0.0043 0.2571
777 0.0019 0.0018 -0.0016 0.0055 0.6201
778 0.0004 0.0018 -0.0032 0.0039 0.1673
779 0.0020 0.0018 -0.0015 0.0056 0.6557
780 0.0009 0.0018 -0.0027 0.0045 0.2835
781 0.0003 0.0018 -0.0032 0.0039 0.1656
782 0.0006 0.0018 -0.0030 0.0042 0.2116
783 0.0008 0.0018 -0.0028 0.0044 0.2587
784 0.0010 0.0018 -0.0026 0.0045 0.2997
785 0.0003 0.0018 -0.0032 0.0039 0.1622
786 0.0019 0.0019 -0.0018 0.0055 0.5911
787 0.0006 0.0018 -0.0029 0.0042 0.2214
788 0.0004 0.0018 -0.0032 0.0039 0.1738
789 0.0040 0.0019 0.0003 0.0078 0.5286
790 0.0013 0.0018 -0.0023 0.0049 0.4005
791 0.0024 0.0019 -0.0012 0.0061 0.8220
792 0.0003 0.0018 -0.0033 0.0038 0.1514
793 0.0012 0.0018 -0.0024 0.0047 0.3533
794 0.0012 0.0018 -0.0024 0.0048 0.3582
795 0.0005 0.0018 -0.0030 0.0041 0.2014
796 0.0009 0.0018 -0.0027 0.0044 0.2771
797 0.0012 0.0018 -0.0023 0.0048 0.3676
798 0.0007 0.0018 -0.0028 0.0043 0.2423
799 0.0003 0.0018 -0.0033 0.0038 0.1568
800 0.0005 0.0018 -0.0031 0.0040 0.1876
801 0.0012 0.0018 -0.0024 0.0047 0.3490
802 0.0010 0.0018 -0.0026 0.0045 0.3059
803 0.0012 0.0018 -0.0023 0.0048 0.3782
804 0.0005 0.0018 -0.0031 0.0040 0.1935
805 0.0007 0.0018 -0.0029 0.0042 0.2273
806 0.0152 0.0022 0.0110 0.0195 0.0000 ***
807 0.0123 0.0021 0.0081 0.0165 0.0000 ***
808 0.0013 0.0018 -0.0023 0.0048 0.3838
809 0.0010 0.0018 -0.0026 0.0045 0.3025
810 0.0021 0.0018 -0.0015 0.0057 0.6808
811 0.0012 0.0018 -0.0024 0.0048 0.3626
812 0.0007 0.0018 -0.0028 0.0043 0.2403
813 0.0021 0.0018 -0.0015 0.0056 0.6662
814 0.0013 0.0018 -0.0023 0.0048 0.3856
815 0.0158 0.0023 0.0113 0.0203 0.0000 ***
816 0.0150 0.0022 0.0107 0.0193 0.0000 ***
817 0.0008 0.0018 -0.0027 0.0044 0.2668
818 0.0006 0.0018 -0.0029 0.0042 0.2189
819 0.0016 0.0018 -0.0019 0.0052 0.5095
820 0.0020 0.0018 -0.0016 0.0056 0.6376
821 0.0068 0.0019 0.0030 0.0106 0.0397 **
822 0.0040 0.0018 0.0004 0.0077 0.5199
823 0.0005 0.0018 -0.0030 0.0041 0.2031
824 0.0005 0.0018 -0.0031 0.0040 0.1942
825 0.0018 0.0018 -0.0017 0.0054 0.5822
826 0.0029 0.0019 -0.0007 0.0065 0.9740
827 0.0017 0.0018 -0.0019 0.0053 0.5219
828 0.0007 0.0018 -0.0029 0.0042 0.2322
829 0.0009 0.0018 -0.0026 0.0045 0.2863
830 0.0006 0.0018 -0.0030 0.0041 0.2080
831 0.0010 0.0018 -0.0026 0.0045 0.2985
==============================================================================
Significant units: 6 / 832
---
Signif. codes: 0 '***' 0.01 '**' 0.05 '*' 0.1 ' ' 1
==============================================================================
=== Z-space feature summary ===
==============================================================================
Feature Importance Results
==============================================================================
Method: EOTExplainer
Number of units: 832
Significance level: 0.05
Alternative: two-sided
Margin method: mixture
Practical margin: 0.0028
------------------------------------------------------------------------------
Feature Estimate Std Err CI Lower CI Upper P-value Sig
------------------------------------------------------------------------------
0 0.0009 0.0020 -0.0031 0.0049 0.3332
1 0.0020 0.0021 -0.0022 0.0062 0.7024
2 0.0020 0.0020 -0.0020 0.0059 0.6660
3 0.0001 0.0020 -0.0038 0.0040 0.1640
4 0.0001 0.0020 -0.0038 0.0040 0.1634
5 0.0012 0.0022 -0.0030 0.0054 0.4550
6 0.0002 0.0020 -0.0037 0.0041 0.1901
7 0.0001 0.0020 -0.0038 0.0040 0.1672
8 0.0002 0.0020 -0.0037 0.0041 0.1834
9 0.0001 0.0020 -0.0037 0.0040 0.1758
10 0.0000 0.0020 -0.0039 0.0039 0.1583
11 0.0010 0.0021 -0.0031 0.0051 0.3872
12 0.0003 0.0020 -0.0035 0.0042 0.2114
13 0.0023 0.0025 -0.0027 0.0073 0.8338
14 0.0028 0.0020 -0.0012 0.0068 0.9902
15 0.0014 0.0021 -0.0027 0.0055 0.4978
16 0.0000 0.0020 -0.0039 0.0039 0.1571
17 0.0019 0.0020 -0.0021 0.0058 0.6315
18 0.0003 0.0020 -0.0036 0.0041 0.1942
19 0.0047 0.0021 0.0006 0.0088 0.3615
20 0.0007 0.0020 -0.0033 0.0047 0.2912
21 0.0000 0.0020 -0.0039 0.0039 0.1588
22 0.0028 0.0020 -0.0012 0.0069 0.9927
23 0.0000 0.0020 -0.0039 0.0039 0.1576
24 0.0006 0.0020 -0.0034 0.0045 0.2564
25 0.0000 0.0020 -0.0038 0.0039 0.1598
26 0.0000 0.0020 -0.0039 0.0039 0.1548
27 0.0003 0.0020 -0.0036 0.0042 0.2060
28 0.0009 0.0020 -0.0030 0.0048 0.3283
29 0.0003 0.0020 -0.0036 0.0042 0.2073
30 0.0001 0.0020 -0.0038 0.0039 0.1626
31 0.0006 0.0020 -0.0033 0.0045 0.2553
32 0.0000 0.0020 -0.0039 0.0039 0.1581
33 0.0004 0.0020 -0.0035 0.0043 0.2148
34 0.0009 0.0020 -0.0030 0.0048 0.3292
35 0.0003 0.0020 -0.0036 0.0042 0.2105
36 0.0009 0.0020 -0.0030 0.0049 0.3487
37 0.0006 0.0020 -0.0034 0.0046 0.2767
38 0.0003 0.0020 -0.0036 0.0042 0.2078
39 0.0001 0.0020 -0.0038 0.0040 0.1636
40 0.0002 0.0020 -0.0037 0.0041 0.1839
41 -0.0000 0.0020 -0.0039 0.0039 0.1500
42 0.0006 0.0020 -0.0033 0.0045 0.2599
43 -0.0000 0.0020 -0.0039 0.0039 0.1535
44 0.0004 0.0020 -0.0035 0.0043 0.2243
45 0.0009 0.0021 -0.0032 0.0050 0.3554
46 0.0004 0.0020 -0.0035 0.0043 0.2242
47 0.0001 0.0020 -0.0038 0.0040 0.1655
48 0.0002 0.0020 -0.0037 0.0041 0.1897
49 0.0008 0.0020 -0.0031 0.0047 0.3141
50 0.0004 0.0020 -0.0035 0.0043 0.2179
51 0.0004 0.0020 -0.0036 0.0043 0.2152
52 0.0010 0.0020 -0.0030 0.0050 0.3668
53 0.0001 0.0020 -0.0038 0.0040 0.1725
54 0.0001 0.0020 -0.0038 0.0040 0.1645
55 0.0001 0.0020 -0.0038 0.0040 0.1645
56 0.0000 0.0020 -0.0039 0.0039 0.1578
57 0.0003 0.0020 -0.0036 0.0042 0.2091
58 0.0038 0.0021 -0.0004 0.0080 0.6416
59 0.0001 0.0020 -0.0038 0.0040 0.1747
60 0.0004 0.0020 -0.0035 0.0043 0.2139
61 0.0006 0.0020 -0.0033 0.0045 0.2608
62 0.0004 0.0020 -0.0035 0.0044 0.2324
63 0.0001 0.0020 -0.0037 0.0040 0.1764
64 0.0001 0.0020 -0.0038 0.0039 0.1613
65 0.0012 0.0021 -0.0029 0.0053 0.4474
66 0.0001 0.0020 -0.0038 0.0039 0.1616
67 -0.0000 0.0020 -0.0039 0.0039 0.1501
68 0.0016 0.0021 -0.0024 0.0057 0.5681
69 0.0002 0.0020 -0.0037 0.0041 0.1799
70 0.0017 0.0021 -0.0023 0.0057 0.5807
71 0.0001 0.0020 -0.0037 0.0040 0.1760
72 0.0007 0.0020 -0.0032 0.0046 0.2828
73 0.0017 0.0020 -0.0022 0.0056 0.5754
74 0.0026 0.0028 -0.0030 0.0082 0.9325
75 0.0002 0.0020 -0.0037 0.0041 0.1825
76 0.0000 0.0020 -0.0038 0.0039 0.1600
77 -0.0002 0.0020 -0.0042 0.0038 0.1335
78 -0.0000 0.0020 -0.0039 0.0039 0.1497
79 0.0033 0.0025 -0.0015 0.0081 0.8515
80 -0.0015 0.0030 -0.0073 0.0043 0.1449
81 -0.0000 0.0020 -0.0039 0.0039 0.1513
82 0.0001 0.0020 -0.0038 0.0040 0.1708
83 0.0002 0.0020 -0.0037 0.0041 0.1877
84 0.0000 0.0020 -0.0039 0.0039 0.1553
85 0.0003 0.0020 -0.0036 0.0041 0.1939
86 0.0003 0.0020 -0.0036 0.0041 0.1947
87 -0.0000 0.0020 -0.0039 0.0039 0.1533
88 0.0047 0.0031 -0.0013 0.0108 0.5390
89 0.0003 0.0020 -0.0036 0.0042 0.1963
90 0.0002 0.0020 -0.0037 0.0041 0.1859
91 -0.0002 0.0021 -0.0042 0.0038 0.1397
92 0.0000 0.0020 -0.0039 0.0039 0.1583
93 0.0010 0.0020 -0.0029 0.0050 0.3741
94 0.0006 0.0020 -0.0033 0.0046 0.2716
95 0.0001 0.0020 -0.0038 0.0040 0.1739
96 0.0001 0.0020 -0.0038 0.0040 0.1648
97 0.0005 0.0020 -0.0034 0.0044 0.2456
98 0.0003 0.0020 -0.0036 0.0042 0.2067
99 0.0001 0.0020 -0.0038 0.0040 0.1690
100 0.0003 0.0020 -0.0036 0.0042 0.2009
101 0.0000 0.0020 -0.0039 0.0039 0.1570
102 0.0013 0.0021 -0.0028 0.0055 0.4822
103 0.0010 0.0020 -0.0030 0.0049 0.3601
104 0.0002 0.0020 -0.0037 0.0041 0.1816
105 0.0011 0.0020 -0.0028 0.0050 0.3919
106 0.0000 0.0020 -0.0039 0.0039 0.1586
107 0.0015 0.0020 -0.0025 0.0054 0.4994
108 0.0011 0.0020 -0.0028 0.0050 0.3902
109 0.0016 0.0021 -0.0025 0.0056 0.5401
110 0.0015 0.0023 -0.0031 0.0060 0.5597
111 0.0008 0.0020 -0.0031 0.0047 0.3053
112 0.0012 0.0020 -0.0028 0.0051 0.4130
113 0.0009 0.0020 -0.0030 0.0048 0.3362
114 0.0000 0.0020 -0.0039 0.0039 0.1555
115 0.0005 0.0020 -0.0035 0.0044 0.2338
116 0.0001 0.0020 -0.0038 0.0039 0.1623
117 0.0010 0.0020 -0.0029 0.0050 0.3668
118 0.0029 0.0021 -0.0012 0.0069 0.9915
119 0.0014 0.0023 -0.0031 0.0058 0.5201
120 0.0004 0.0020 -0.0035 0.0043 0.2191
121 0.0000 0.0020 -0.0039 0.0039 0.1618
122 0.0010 0.0020 -0.0030 0.0049 0.3558
123 0.0019 0.0021 -0.0023 0.0060 0.6433
124 0.0001 0.0020 -0.0038 0.0040 0.1704
125 0.0004 0.0020 -0.0035 0.0043 0.2155
126 -0.0000 0.0020 -0.0039 0.0038 0.1470
127 0.0005 0.0020 -0.0034 0.0044 0.2362
128 0.0000 0.0020 -0.0039 0.0039 0.1592
129 -0.0000 0.0020 -0.0039 0.0039 0.1528
130 0.0002 0.0020 -0.0037 0.0041 0.1898
131 0.0003 0.0020 -0.0035 0.0042 0.2115
132 0.0003 0.0020 -0.0036 0.0042 0.2077
133 0.0002 0.0020 -0.0037 0.0041 0.1915
134 0.0004 0.0020 -0.0036 0.0043 0.2238
135 0.0006 0.0020 -0.0033 0.0045 0.2677
136 0.0014 0.0021 -0.0026 0.0054 0.4870
137 0.0004 0.0020 -0.0035 0.0043 0.2228
138 0.0000 0.0020 -0.0039 0.0039 0.1580
139 0.0005 0.0020 -0.0034 0.0044 0.2421
140 -0.0001 0.0020 -0.0039 0.0038 0.1463
141 0.0002 0.0020 -0.0037 0.0041 0.1828
142 0.0002 0.0020 -0.0037 0.0041 0.1811
143 0.0000 0.0020 -0.0039 0.0039 0.1591
144 0.0000 0.0020 -0.0039 0.0039 0.1574
145 -0.0000 0.0020 -0.0039 0.0039 0.1516
146 0.0000 0.0020 -0.0039 0.0039 0.1593
147 0.0001 0.0020 -0.0038 0.0040 0.1640
148 -0.0001 0.0020 -0.0039 0.0038 0.1461
149 0.0001 0.0020 -0.0038 0.0040 0.1736
150 0.0007 0.0020 -0.0032 0.0046 0.2744
151 0.0009 0.0020 -0.0030 0.0048 0.3414
152 0.0014 0.0020 -0.0025 0.0053 0.4720
153 0.0000 0.0020 -0.0038 0.0039 0.1607
154 0.0002 0.0020 -0.0037 0.0041 0.1824
155 0.0000 0.0020 -0.0039 0.0039 0.1542
156 0.0001 0.0020 -0.0037 0.0040 0.1766
157 0.0006 0.0020 -0.0033 0.0045 0.2623
158 0.0007 0.0020 -0.0032 0.0046 0.2778
159 0.0002 0.0020 -0.0037 0.0041 0.1785
160 -0.0001 0.0020 -0.0039 0.0038 0.1453
161 0.0009 0.0020 -0.0030 0.0049 0.3427
162 0.0001 0.0020 -0.0038 0.0039 0.1619
163 0.0000 0.0020 -0.0039 0.0039 0.1546
164 0.0001 0.0020 -0.0038 0.0040 0.1641
165 0.0002 0.0020 -0.0037 0.0041 0.1915
166 0.0027 0.0021 -0.0015 0.0068 0.9330
167 -0.0000 0.0020 -0.0039 0.0039 0.1506
168 -0.0000 0.0020 -0.0039 0.0039 0.1515
169 0.0011 0.0020 -0.0028 0.0051 0.3925
170 0.0006 0.0020 -0.0033 0.0046 0.2771
171 0.0000 0.0020 -0.0039 0.0039 0.1539
172 0.0003 0.0020 -0.0036 0.0042 0.2033
173 0.0001 0.0020 -0.0038 0.0040 0.1687
174 0.0003 0.0020 -0.0037 0.0042 0.1967
175 0.0004 0.0020 -0.0035 0.0043 0.2205
176 0.0008 0.0020 -0.0031 0.0047 0.3025
177 0.0004 0.0020 -0.0035 0.0044 0.2401
178 0.0001 0.0020 -0.0038 0.0040 0.1664
179 -0.0000 0.0020 -0.0039 0.0039 0.1494
180 0.0005 0.0020 -0.0034 0.0044 0.2485
181 0.0005 0.0020 -0.0034 0.0044 0.2337
182 0.0013 0.0021 -0.0027 0.0053 0.4608
183 0.0009 0.0020 -0.0030 0.0049 0.3435
184 -0.0000 0.0020 -0.0039 0.0039 0.1509
185 0.0001 0.0020 -0.0038 0.0040 0.1647
186 0.0018 0.0021 -0.0023 0.0058 0.6115
187 0.0001 0.0020 -0.0038 0.0040 0.1708
188 -0.0000 0.0020 -0.0039 0.0039 0.1518
189 0.0001 0.0020 -0.0038 0.0040 0.1704
190 0.0001 0.0020 -0.0038 0.0039 0.1622
191 0.0013 0.0020 -0.0027 0.0053 0.4524
192 0.0011 0.0020 -0.0028 0.0050 0.3766
193 0.0006 0.0020 -0.0033 0.0045 0.2674
194 0.0001 0.0020 -0.0038 0.0040 0.1746
195 0.0024 0.0021 -0.0016 0.0064 0.8268
196 0.0005 0.0020 -0.0034 0.0044 0.2383
197 0.0010 0.0020 -0.0030 0.0049 0.3617
198 0.0022 0.0021 -0.0019 0.0063 0.7683
199 0.0003 0.0020 -0.0036 0.0042 0.2060
200 -0.0000 0.0020 -0.0039 0.0039 0.1508
201 0.0001 0.0020 -0.0038 0.0039 0.1619
202 0.0001 0.0020 -0.0038 0.0040 0.1726
203 -0.0000 0.0020 -0.0039 0.0039 0.1515
204 0.0000 0.0020 -0.0038 0.0039 0.1608
205 0.0002 0.0020 -0.0037 0.0041 0.1877
206 0.0001 0.0020 -0.0038 0.0039 0.1617
207 0.0001 0.0020 -0.0038 0.0040 0.1695
208 0.0002 0.0020 -0.0037 0.0041 0.1838
209 0.0005 0.0020 -0.0034 0.0044 0.2348
210 0.0001 0.0020 -0.0038 0.0040 0.1659
211 -0.0000 0.0020 -0.0039 0.0038 0.1478
212 0.0003 0.0020 -0.0036 0.0043 0.2169
213 0.0000 0.0020 -0.0039 0.0039 0.1552
214 0.0002 0.0020 -0.0037 0.0041 0.1853
215 0.0001 0.0020 -0.0038 0.0039 0.1613
216 0.0003 0.0020 -0.0036 0.0042 0.1981
217 0.0002 0.0020 -0.0037 0.0040 0.1779
218 0.0003 0.0020 -0.0036 0.0042 0.2061
219 0.0001 0.0020 -0.0038 0.0039 0.1627
220 0.0005 0.0020 -0.0034 0.0045 0.2525
221 0.0001 0.0020 -0.0038 0.0040 0.1681
222 0.0002 0.0020 -0.0037 0.0041 0.1843
223 0.0000 0.0020 -0.0038 0.0039 0.1609
224 0.0002 0.0020 -0.0037 0.0041 0.1884
225 0.0000 0.0020 -0.0039 0.0039 0.1580
226 0.0036 0.0020 -0.0004 0.0076 0.7174
227 0.0001 0.0020 -0.0038 0.0040 0.1698
228 0.0004 0.0020 -0.0035 0.0042 0.2119
229 0.0003 0.0020 -0.0036 0.0042 0.1955
230 0.0000 0.0020 -0.0039 0.0039 0.1592
231 -0.0000 0.0020 -0.0039 0.0039 0.1513
232 0.0001 0.0020 -0.0038 0.0040 0.1703
233 0.0011 0.0020 -0.0029 0.0050 0.3782
234 -0.0000 0.0020 -0.0039 0.0039 0.1486
235 0.0000 0.0020 -0.0039 0.0039 0.1586
236 0.0001 0.0020 -0.0038 0.0039 0.1613
237 0.0002 0.0020 -0.0037 0.0041 0.1794
238 0.0005 0.0020 -0.0035 0.0044 0.2346
239 0.0003 0.0020 -0.0036 0.0042 0.2010
240 0.0023 0.0020 -0.0017 0.0063 0.7878
241 0.0012 0.0020 -0.0027 0.0052 0.4302
242 0.0000 0.0020 -0.0039 0.0039 0.1591
243 0.0024 0.0020 -0.0016 0.0064 0.8403
244 0.0001 0.0020 -0.0038 0.0040 0.1627
245 0.0003 0.0020 -0.0036 0.0042 0.1998
246 0.0012 0.0021 -0.0028 0.0052 0.4327
247 0.0004 0.0020 -0.0034 0.0043 0.2300
248 0.0003 0.0020 -0.0036 0.0042 0.2071
249 0.0000 0.0020 -0.0039 0.0039 0.1572
250 0.0001 0.0020 -0.0038 0.0040 0.1686
251 0.0008 0.0020 -0.0032 0.0048 0.3103
252 0.0004 0.0020 -0.0035 0.0043 0.2265
253 0.0001 0.0020 -0.0038 0.0040 0.1763
254 0.0014 0.0020 -0.0026 0.0053 0.4660
255 0.0004 0.0020 -0.0035 0.0043 0.2177
256 0.0005 0.0020 -0.0034 0.0044 0.2429
257 0.0000 0.0020 -0.0039 0.0039 0.1570
258 0.0002 0.0020 -0.0037 0.0041 0.1881
259 0.0001 0.0020 -0.0038 0.0040 0.1741
260 0.0000 0.0020 -0.0039 0.0039 0.1593
261 0.0018 0.0021 -0.0022 0.0059 0.6275
262 0.0006 0.0020 -0.0033 0.0045 0.2690
263 0.0004 0.0020 -0.0035 0.0043 0.2254
264 0.0000 0.0020 -0.0038 0.0039 0.1597
265 0.0000 0.0020 -0.0039 0.0039 0.1583
266 0.0015 0.0020 -0.0024 0.0054 0.5050
267 0.0001 0.0020 -0.0038 0.0040 0.1725
268 0.0002 0.0020 -0.0037 0.0041 0.1831
269 0.0003 0.0020 -0.0036 0.0042 0.2052
270 0.0002 0.0020 -0.0037 0.0041 0.1818
271 0.0019 0.0020 -0.0021 0.0059 0.6488
272 0.0005 0.0020 -0.0034 0.0044 0.2416
273 0.0000 0.0020 -0.0039 0.0039 0.1588
274 0.0000 0.0020 -0.0038 0.0039 0.1596
275 0.0003 0.0020 -0.0036 0.0042 0.2025
276 0.0009 0.0020 -0.0030 0.0048 0.3402
277 0.0009 0.0020 -0.0030 0.0049 0.3450
278 0.0009 0.0020 -0.0030 0.0048 0.3239
279 0.0006 0.0020 -0.0033 0.0045 0.2618
280 0.0004 0.0020 -0.0035 0.0043 0.2285
281 0.0017 0.0020 -0.0022 0.0057 0.5826
282 -0.0000 0.0020 -0.0039 0.0039 0.1493
283 0.0018 0.0020 -0.0021 0.0057 0.6064
284 0.0001 0.0020 -0.0038 0.0040 0.1652
285 0.0005 0.0020 -0.0034 0.0044 0.2457
286 0.0000 0.0020 -0.0039 0.0039 0.1580
287 0.0048 0.0026 -0.0003 0.0099 0.4579
288 0.0003 0.0020 -0.0036 0.0042 0.2096
289 0.0005 0.0020 -0.0034 0.0043 0.2316
290 0.0001 0.0020 -0.0038 0.0040 0.1732
291 0.0012 0.0020 -0.0027 0.0051 0.4171
292 0.0002 0.0020 -0.0037 0.0041 0.1915
293 0.0007 0.0021 -0.0033 0.0048 0.3156
294 0.0010 0.0020 -0.0029 0.0050 0.3694
295 0.0010 0.0020 -0.0029 0.0048 0.3445
296 0.0000 0.0020 -0.0039 0.0039 0.1582
297 0.0001 0.0020 -0.0038 0.0039 0.1621
298 0.0001 0.0020 -0.0038 0.0040 0.1711
299 0.0017 0.0020 -0.0023 0.0056 0.5726
300 0.0009 0.0020 -0.0031 0.0048 0.3247
301 0.0017 0.0022 -0.0026 0.0060 0.6056
302 0.0000 0.0020 -0.0038 0.0039 0.1596
303 0.0013 0.0020 -0.0027 0.0052 0.4392
304 0.0001 0.0020 -0.0037 0.0040 0.1756
305 0.0001 0.0020 -0.0038 0.0040 0.1739
306 0.0005 0.0020 -0.0034 0.0045 0.2543
307 0.0011 0.0022 -0.0031 0.0054 0.4303
308 0.0002 0.0020 -0.0037 0.0040 0.1778
309 0.0005 0.0020 -0.0034 0.0044 0.2497
310 0.0001 0.0020 -0.0038 0.0040 0.1683
311 0.0008 0.0020 -0.0031 0.0048 0.3165
312 0.0001 0.0020 -0.0038 0.0040 0.1713
313 0.0019 0.0020 -0.0020 0.0058 0.6434
314 0.0006 0.0020 -0.0033 0.0045 0.2608
315 0.0012 0.0020 -0.0028 0.0051 0.4058
316 0.0002 0.0020 -0.0037 0.0040 0.1774
317 0.0028 0.0020 -0.0012 0.0067 0.9699
318 0.0016 0.0020 -0.0023 0.0056 0.5481
319 -0.0000 0.0020 -0.0039 0.0038 0.1476
320 0.0004 0.0020 -0.0035 0.0042 0.2120
321 0.0017 0.0020 -0.0022 0.0057 0.5928
322 0.0002 0.0020 -0.0037 0.0041 0.1831
323 0.0000 0.0020 -0.0039 0.0039 0.1585
324 0.0001 0.0020 -0.0038 0.0040 0.1663
325 0.0005 0.0020 -0.0035 0.0045 0.2513
326 0.0021 0.0020 -0.0019 0.0060 0.7025
327 0.0001 0.0020 -0.0038 0.0040 0.1669
328 0.0001 0.0020 -0.0038 0.0040 0.1643
329 0.0036 0.0021 -0.0005 0.0077 0.7033
330 0.0032 0.0020 -0.0008 0.0072 0.8594
331 -0.0000 0.0020 -0.0039 0.0039 0.1522
332 0.0003 0.0020 -0.0036 0.0042 0.2121
333 0.0101 0.0023 0.0055 0.0147 0.0019 ***
334 0.0001 0.0020 -0.0038 0.0040 0.1672
335 0.0010 0.0020 -0.0030 0.0049 0.3562
336 0.0001 0.0020 -0.0038 0.0039 0.1626
337 0.0009 0.0020 -0.0030 0.0049 0.3468
338 0.0018 0.0021 -0.0023 0.0058 0.6092
339 0.0003 0.0020 -0.0036 0.0043 0.2119
340 0.0009 0.0020 -0.0031 0.0049 0.3430
341 0.0017 0.0020 -0.0022 0.0057 0.5837
342 0.0001 0.0020 -0.0038 0.0039 0.1622
343 0.0025 0.0020 -0.0015 0.0064 0.8517
344 0.0004 0.0020 -0.0035 0.0043 0.2282
345 0.0014 0.0020 -0.0026 0.0054 0.4849
346 0.0011 0.0021 -0.0029 0.0052 0.4124
347 0.0012 0.0020 -0.0027 0.0052 0.4269
348 0.0001 0.0020 -0.0038 0.0040 0.1688
349 0.0003 0.0020 -0.0036 0.0042 0.1982
350 0.0040 0.0020 0.0000 0.0080 0.5637
351 0.0000 0.0020 -0.0039 0.0039 0.1546
352 0.0002 0.0020 -0.0037 0.0041 0.1814
353 0.0012 0.0020 -0.0028 0.0052 0.4243
354 0.0014 0.0020 -0.0025 0.0054 0.4913
355 0.0005 0.0020 -0.0034 0.0044 0.2337
356 0.0001 0.0020 -0.0038 0.0040 0.1726
357 0.0010 0.0020 -0.0030 0.0050 0.3782
358 0.0004 0.0020 -0.0035 0.0043 0.2248
359 0.0002 0.0020 -0.0037 0.0041 0.1923
360 0.0002 0.0020 -0.0037 0.0041 0.1903
361 0.0006 0.0020 -0.0033 0.0045 0.2684
362 0.0020 0.0022 -0.0023 0.0063 0.7010
363 0.0002 0.0020 -0.0036 0.0041 0.1921
364 0.0003 0.0020 -0.0036 0.0042 0.2039
365 0.0025 0.0020 -0.0015 0.0065 0.8669
366 0.0072 0.0023 0.0027 0.0117 0.0551 *
367 0.0007 0.0020 -0.0032 0.0046 0.2741
368 0.0008 0.0020 -0.0031 0.0047 0.3037
369 0.0006 0.0020 -0.0033 0.0045 0.2567
370 0.0002 0.0020 -0.0037 0.0041 0.1894
371 0.0002 0.0020 -0.0037 0.0041 0.1867
372 0.0011 0.0020 -0.0028 0.0051 0.4013
373 0.0001 0.0020 -0.0038 0.0040 0.1667
374 0.0015 0.0020 -0.0025 0.0054 0.4922
375 0.0015 0.0021 -0.0025 0.0055 0.5115
376 0.0011 0.0020 -0.0028 0.0050 0.3778
377 0.0009 0.0020 -0.0031 0.0048 0.3345
378 0.0001 0.0020 -0.0038 0.0040 0.1717
379 0.0010 0.0021 -0.0032 0.0053 0.4057
380 0.0005 0.0020 -0.0034 0.0044 0.2500
381 0.0001 0.0020 -0.0038 0.0039 0.1611
382 0.0005 0.0020 -0.0034 0.0045 0.2517
383 0.0005 0.0020 -0.0034 0.0045 0.2523
384 -0.0000 0.0020 -0.0039 0.0039 0.1504
385 0.0000 0.0020 -0.0039 0.0039 0.1593
386 0.0031 0.0020 -0.0009 0.0071 0.8906
387 0.0004 0.0020 -0.0035 0.0043 0.2251
388 0.0000 0.0020 -0.0039 0.0039 0.1578
389 0.0003 0.0020 -0.0036 0.0042 0.1958
390 -0.0000 0.0020 -0.0039 0.0039 0.1531
391 0.0019 0.0020 -0.0021 0.0058 0.6260
392 0.0011 0.0020 -0.0029 0.0050 0.3734
393 0.0011 0.0021 -0.0029 0.0051 0.4040
394 0.0001 0.0020 -0.0037 0.0040 0.1760
395 0.0001 0.0020 -0.0038 0.0040 0.1737
396 0.0007 0.0020 -0.0032 0.0047 0.2997
397 0.0002 0.0020 -0.0037 0.0041 0.1902
398 0.0002 0.0020 -0.0037 0.0041 0.1911
399 0.0001 0.0020 -0.0038 0.0040 0.1711
400 0.0000 0.0020 -0.0039 0.0039 0.1545
401 0.0005 0.0020 -0.0034 0.0044 0.2479
402 0.0000 0.0020 -0.0039 0.0039 0.1553
403 -0.0000 0.0020 -0.0039 0.0039 0.1504
404 0.0011 0.0020 -0.0028 0.0050 0.3876
405 0.0001 0.0020 -0.0037 0.0040 0.1752
406 0.0006 0.0020 -0.0034 0.0045 0.2619
407 0.0004 0.0020 -0.0035 0.0043 0.2266
408 -0.0000 0.0020 -0.0039 0.0039 0.1502
409 0.0012 0.0020 -0.0027 0.0052 0.4308
410 0.0004 0.0020 -0.0035 0.0044 0.2312
411 0.0001 0.0020 -0.0038 0.0040 0.1741
412 0.0001 0.0020 -0.0038 0.0040 0.1725
413 0.0003 0.0020 -0.0036 0.0042 0.1960
414 -0.0000 0.0020 -0.0039 0.0039 0.1494
415 0.0004 0.0020 -0.0035 0.0044 0.2335
416 0.0005 0.0020 -0.0034 0.0044 0.2343
417 -0.0001 0.0020 -0.0040 0.0038 0.1440
418 0.0004 0.0020 -0.0035 0.0043 0.2276
419 0.0007 0.0020 -0.0032 0.0046 0.2802
420 -0.0000 0.0020 -0.0039 0.0039 0.1534
421 0.0000 0.0020 -0.0039 0.0039 0.1539
422 0.0005 0.0020 -0.0034 0.0044 0.2495
423 0.0003 0.0020 -0.0035 0.0042 0.2105
424 0.0016 0.0020 -0.0023 0.0056 0.5452
425 0.0006 0.0020 -0.0033 0.0045 0.2672
426 0.0006 0.0020 -0.0033 0.0045 0.2624
427 0.0002 0.0020 -0.0037 0.0041 0.1798
428 0.0005 0.0020 -0.0034 0.0045 0.2585
429 0.0001 0.0020 -0.0038 0.0040 0.1656
430 0.0001 0.0020 -0.0038 0.0040 0.1676
431 0.0002 0.0020 -0.0037 0.0041 0.1827
432 0.0001 0.0020 -0.0038 0.0040 0.1704
433 0.0001 0.0020 -0.0038 0.0040 0.1683
434 0.0003 0.0020 -0.0036 0.0042 0.2006
435 0.0000 0.0020 -0.0038 0.0039 0.1596
436 0.0001 0.0020 -0.0038 0.0040 0.1733
437 0.0028 0.0020 -0.0012 0.0068 0.9986
438 0.0001 0.0020 -0.0037 0.0040 0.1764
439 -0.0000 0.0020 -0.0039 0.0039 0.1503
440 0.0025 0.0021 -0.0015 0.0065 0.8670
441 0.0008 0.0020 -0.0031 0.0047 0.3141
442 0.0001 0.0020 -0.0038 0.0040 0.1644
443 0.0002 0.0020 -0.0036 0.0041 0.1925
444 -0.0000 0.0020 -0.0039 0.0039 0.1502
445 0.0002 0.0020 -0.0037 0.0041 0.1891
446 -0.0001 0.0020 -0.0039 0.0038 0.1456
447 0.0009 0.0020 -0.0031 0.0049 0.3463
448 0.0000 0.0020 -0.0039 0.0039 0.1574
449 0.0001 0.0020 -0.0038 0.0040 0.1661
450 -0.0000 0.0020 -0.0039 0.0039 0.1515
451 0.0006 0.0020 -0.0034 0.0045 0.2570
452 0.0012 0.0020 -0.0027 0.0051 0.4217
453 0.0004 0.0020 -0.0035 0.0043 0.2177
454 0.0022 0.0020 -0.0017 0.0062 0.7691
455 0.0001 0.0020 -0.0038 0.0040 0.1666
456 0.0006 0.0020 -0.0033 0.0045 0.2670
457 0.0005 0.0020 -0.0035 0.0044 0.2369
458 0.0001 0.0020 -0.0038 0.0040 0.1655
459 0.0004 0.0020 -0.0035 0.0043 0.2132
460 0.0004 0.0020 -0.0035 0.0043 0.2248
461 0.0001 0.0020 -0.0038 0.0040 0.1670
462 0.0001 0.0020 -0.0038 0.0040 0.1733
463 0.0056 0.0026 0.0006 0.0106 0.2846
464 0.0008 0.0020 -0.0031 0.0047 0.3061
465 0.0003 0.0020 -0.0036 0.0042 0.2012
466 0.0005 0.0020 -0.0034 0.0043 0.2318
467 0.0020 0.0021 -0.0020 0.0061 0.7040
468 0.0003 0.0020 -0.0036 0.0041 0.1943
469 0.0006 0.0020 -0.0033 0.0045 0.2556
470 0.0003 0.0020 -0.0036 0.0042 0.2070
471 0.0009 0.0021 -0.0032 0.0050 0.3591
472 0.0018 0.0020 -0.0022 0.0058 0.6113
473 0.0045 0.0021 0.0004 0.0086 0.4313
474 0.0004 0.0020 -0.0035 0.0043 0.2161
475 0.0006 0.0020 -0.0033 0.0045 0.2629
476 -0.0000 0.0020 -0.0039 0.0039 0.1504
477 0.0000 0.0020 -0.0039 0.0039 0.1539
478 0.0003 0.0020 -0.0036 0.0042 0.1975
479 0.0006 0.0020 -0.0033 0.0045 0.2697
480 0.0001 0.0020 -0.0038 0.0040 0.1664
481 0.0000 0.0020 -0.0039 0.0039 0.1546
482 0.0002 0.0020 -0.0036 0.0041 0.1941
483 0.0002 0.0020 -0.0036 0.0041 0.1933
484 0.0000 0.0020 -0.0039 0.0039 0.1555
485 0.0004 0.0020 -0.0035 0.0043 0.2250
486 0.0009 0.0022 -0.0034 0.0051 0.3604
487 0.0009 0.0020 -0.0030 0.0049 0.3427
488 0.0021 0.0020 -0.0018 0.0061 0.7252
489 0.0006 0.0020 -0.0034 0.0047 0.2848
490 0.0003 0.0020 -0.0036 0.0042 0.1986
491 0.0008 0.0021 -0.0032 0.0049 0.3338
492 0.0003 0.0020 -0.0036 0.0042 0.2043
493 0.0001 0.0020 -0.0038 0.0040 0.1691
494 0.0056 0.0021 0.0015 0.0096 0.1849
495 0.0004 0.0020 -0.0035 0.0043 0.2272
496 0.0002 0.0020 -0.0037 0.0041 0.1829
497 0.0010 0.0020 -0.0030 0.0050 0.3725
498 0.0009 0.0021 -0.0033 0.0051 0.3651
499 0.0002 0.0020 -0.0037 0.0041 0.1844
500 0.0002 0.0020 -0.0037 0.0041 0.1836
501 0.0006 0.0020 -0.0033 0.0045 0.2660
502 0.0000 0.0020 -0.0039 0.0039 0.1556
503 0.0001 0.0020 -0.0038 0.0040 0.1704
504 0.0001 0.0020 -0.0038 0.0040 0.1737
505 0.0005 0.0020 -0.0034 0.0044 0.2373
506 0.0010 0.0020 -0.0029 0.0049 0.3650
507 0.0001 0.0020 -0.0038 0.0040 0.1732
508 0.0007 0.0021 -0.0033 0.0047 0.2941
509 0.0004 0.0020 -0.0035 0.0043 0.2259
510 0.0006 0.0020 -0.0033 0.0045 0.2550
511 -0.0000 0.0020 -0.0039 0.0039 0.1528
512 0.0001 0.0020 -0.0038 0.0040 0.1647
513 0.0007 0.0020 -0.0032 0.0046 0.2812
514 0.0100 0.0025 0.0052 0.0149 0.0036 ***
515 0.0001 0.0020 -0.0038 0.0040 0.1628
516 0.0001 0.0020 -0.0038 0.0040 0.1659
517 0.0026 0.0020 -0.0014 0.0066 0.9094
518 0.0001 0.0020 -0.0038 0.0040 0.1691
519 0.0015 0.0020 -0.0025 0.0055 0.5206
520 0.0001 0.0020 -0.0038 0.0040 0.1696
521 0.0000 0.0020 -0.0039 0.0039 0.1577
522 0.0008 0.0020 -0.0031 0.0047 0.3000
523 0.0002 0.0020 -0.0037 0.0041 0.1816
524 0.0008 0.0020 -0.0031 0.0047 0.3099
525 0.0007 0.0020 -0.0032 0.0046 0.2887
526 0.0009 0.0020 -0.0030 0.0048 0.3397
527 0.0008 0.0020 -0.0031 0.0047 0.3034
528 0.0000 0.0020 -0.0038 0.0039 0.1607
529 0.0000 0.0020 -0.0038 0.0039 0.1600
530 0.0002 0.0020 -0.0037 0.0041 0.1823
531 0.0009 0.0020 -0.0030 0.0048 0.3318
532 0.0003 0.0020 -0.0036 0.0042 0.2030
533 0.0005 0.0020 -0.0034 0.0044 0.2324
534 0.0002 0.0020 -0.0037 0.0041 0.1832
535 0.0003 0.0020 -0.0036 0.0042 0.2081
536 0.0009 0.0020 -0.0031 0.0048 0.3322
537 0.0001 0.0020 -0.0038 0.0040 0.1705
538 0.0004 0.0020 -0.0035 0.0043 0.2172
539 0.0008 0.0020 -0.0032 0.0048 0.3275
540 0.0006 0.0020 -0.0033 0.0045 0.2625
541 -0.0000 0.0020 -0.0039 0.0039 0.1526
542 0.0002 0.0020 -0.0037 0.0041 0.1828
543 0.0008 0.0020 -0.0031 0.0047 0.3054
544 0.0006 0.0020 -0.0033 0.0045 0.2675
545 0.0000 0.0020 -0.0039 0.0039 0.1547
546 0.0003 0.0020 -0.0036 0.0042 0.1990
547 0.0003 0.0020 -0.0036 0.0042 0.2049
548 0.0043 0.0021 0.0002 0.0084 0.4929
549 0.0005 0.0020 -0.0034 0.0045 0.2530
550 0.0039 0.0021 -0.0002 0.0079 0.6210
551 0.0022 0.0022 -0.0021 0.0065 0.7589
552 0.0006 0.0020 -0.0033 0.0046 0.2780
553 0.0001 0.0020 -0.0038 0.0039 0.1627
554 0.0000 0.0020 -0.0039 0.0039 0.1559
555 0.0009 0.0020 -0.0030 0.0049 0.3446
556 0.0003 0.0020 -0.0036 0.0042 0.1985
557 -0.0000 0.0020 -0.0039 0.0039 0.1487
558 0.0014 0.0020 -0.0025 0.0053 0.4783
559 0.0001 0.0020 -0.0038 0.0040 0.1699
560 0.0001 0.0020 -0.0038 0.0040 0.1665
561 0.0039 0.0021 -0.0003 0.0080 0.6268
562 0.0020 0.0020 -0.0020 0.0060 0.6882
563 0.0005 0.0020 -0.0033 0.0044 0.2503
564 0.0010 0.0021 -0.0031 0.0051 0.3807
565 0.0071 0.0022 0.0028 0.0113 0.0503 *
566 0.0001 0.0020 -0.0038 0.0040 0.1726
567 0.0000 0.0020 -0.0038 0.0039 0.1606
568 0.0001 0.0020 -0.0038 0.0040 0.1750
569 0.0002 0.0020 -0.0037 0.0041 0.1880
570 0.0025 0.0022 -0.0018 0.0068 0.8767
571 0.0003 0.0020 -0.0036 0.0042 0.2059
572 0.0000 0.0020 -0.0039 0.0039 0.1570
573 0.0001 0.0020 -0.0038 0.0039 0.1623
574 0.0006 0.0020 -0.0034 0.0046 0.2727
575 0.0000 0.0020 -0.0039 0.0039 0.1538
576 0.0006 0.0020 -0.0033 0.0045 0.2688
577 0.0003 0.0020 -0.0036 0.0042 0.1995
578 0.0002 0.0020 -0.0037 0.0041 0.1912
579 0.0005 0.0020 -0.0035 0.0044 0.2381
580 0.0007 0.0020 -0.0032 0.0046 0.2879
581 0.0024 0.0022 -0.0019 0.0067 0.8472
582 0.0016 0.0020 -0.0024 0.0056 0.5524
583 0.0002 0.0020 -0.0037 0.0041 0.1867
584 0.0000 0.0020 -0.0039 0.0039 0.1576
585 0.0015 0.0022 -0.0028 0.0057 0.5338
586 0.0008 0.0021 -0.0033 0.0048 0.3180
587 0.0001 0.0020 -0.0037 0.0040 0.1761
588 0.0006 0.0020 -0.0033 0.0045 0.2606
589 0.0001 0.0020 -0.0038 0.0040 0.1691
590 0.0012 0.0020 -0.0027 0.0051 0.4156
591 0.0001 0.0020 -0.0038 0.0040 0.1652
592 0.0003 0.0020 -0.0036 0.0041 0.1950
593 -0.0001 0.0020 -0.0039 0.0038 0.1463
594 0.0003 0.0020 -0.0036 0.0042 0.2039
595 0.0008 0.0020 -0.0031 0.0048 0.3283
596 0.0001 0.0020 -0.0038 0.0040 0.1710
597 -0.0000 0.0020 -0.0039 0.0039 0.1506
598 0.0002 0.0020 -0.0037 0.0041 0.1863
599 0.0001 0.0020 -0.0038 0.0040 0.1722
600 0.0004 0.0020 -0.0035 0.0043 0.2194
601 0.0001 0.0020 -0.0038 0.0040 0.1683
602 0.0000 0.0020 -0.0039 0.0039 0.1584
603 0.0005 0.0020 -0.0034 0.0044 0.2464
604 0.0008 0.0021 -0.0033 0.0049 0.3334
605 0.0006 0.0020 -0.0033 0.0045 0.2620
606 0.0001 0.0020 -0.0038 0.0040 0.1653
607 0.0001 0.0020 -0.0038 0.0039 0.1615
608 0.0004 0.0020 -0.0035 0.0043 0.2161
609 0.0000 0.0020 -0.0039 0.0039 0.1568
610 -0.0000 0.0020 -0.0039 0.0039 0.1529
611 0.0003 0.0020 -0.0036 0.0042 0.1976
612 0.0002 0.0020 -0.0037 0.0040 0.1773
613 0.0001 0.0020 -0.0038 0.0040 0.1703
614 0.0032 0.0026 -0.0019 0.0084 0.8811
615 0.0006 0.0020 -0.0033 0.0045 0.2593
616 0.0005 0.0020 -0.0033 0.0044 0.2506
617 0.0001 0.0020 -0.0038 0.0040 0.1681
618 0.0005 0.0020 -0.0034 0.0044 0.2397
619 -0.0001 0.0020 -0.0040 0.0038 0.1449
620 0.0011 0.0020 -0.0029 0.0050 0.3819
621 0.0001 0.0020 -0.0038 0.0040 0.1710
622 0.0003 0.0020 -0.0036 0.0042 0.2001
623 -0.0000 0.0020 -0.0039 0.0039 0.1511
624 0.0007 0.0020 -0.0033 0.0047 0.2911
625 0.0000 0.0020 -0.0039 0.0039 0.1562
626 0.0007 0.0020 -0.0032 0.0046 0.2841
627 0.0002 0.0020 -0.0037 0.0041 0.1884
628 0.0003 0.0020 -0.0036 0.0042 0.2050
629 0.0001 0.0020 -0.0037 0.0040 0.1766
630 0.0050 0.0021 0.0009 0.0090 0.2995
631 0.0004 0.0020 -0.0035 0.0043 0.2219
632 0.0001 0.0020 -0.0038 0.0040 0.1691
633 0.0003 0.0020 -0.0036 0.0042 0.1992
634 0.0022 0.0020 -0.0018 0.0062 0.7538
635 0.0000 0.0020 -0.0039 0.0039 0.1559
636 0.0002 0.0020 -0.0037 0.0041 0.1840
637 0.0004 0.0020 -0.0035 0.0043 0.2245
638 0.0002 0.0020 -0.0037 0.0041 0.1783
639 0.0004 0.0020 -0.0035 0.0043 0.2296
640 0.0002 0.0020 -0.0037 0.0041 0.1857
641 0.0000 0.0020 -0.0039 0.0039 0.1576
642 0.0004 0.0020 -0.0035 0.0043 0.2299
643 0.0001 0.0020 -0.0038 0.0040 0.1670
644 0.0003 0.0020 -0.0036 0.0042 0.1961
645 0.0000 0.0020 -0.0039 0.0039 0.1585
646 0.0002 0.0020 -0.0037 0.0041 0.1791
647 0.0010 0.0020 -0.0029 0.0049 0.3619
648 0.0020 0.0020 -0.0020 0.0060 0.6903
649 0.0001 0.0020 -0.0038 0.0040 0.1654
650 0.0000 0.0020 -0.0039 0.0039 0.1588
651 0.0005 0.0020 -0.0034 0.0043 0.2314
652 0.0000 0.0020 -0.0039 0.0039 0.1555
653 0.0003 0.0020 -0.0036 0.0042 0.2005
654 0.0000 0.0020 -0.0038 0.0039 0.1603
655 0.0008 0.0020 -0.0031 0.0047 0.3026
656 0.0002 0.0020 -0.0037 0.0041 0.1820
657 0.0008 0.0020 -0.0031 0.0048 0.3244
658 0.0012 0.0020 -0.0027 0.0052 0.4230
659 0.0008 0.0020 -0.0032 0.0048 0.3248
660 0.0005 0.0020 -0.0034 0.0044 0.2414
661 0.0001 0.0020 -0.0038 0.0040 0.1691
662 0.0010 0.0020 -0.0030 0.0049 0.3494
663 0.0002 0.0020 -0.0037 0.0041 0.1810
664 -0.0000 0.0020 -0.0039 0.0039 0.1533
665 0.0011 0.0020 -0.0029 0.0051 0.3912
666 0.0005 0.0020 -0.0034 0.0044 0.2380
667 0.0002 0.0020 -0.0037 0.0041 0.1864
668 0.0005 0.0020 -0.0034 0.0044 0.2467
669 -0.0001 0.0020 -0.0039 0.0038 0.1458
670 0.0001 0.0020 -0.0038 0.0040 0.1635
671 0.0000 0.0020 -0.0039 0.0039 0.1571
672 0.0006 0.0020 -0.0033 0.0045 0.2703
673 0.0015 0.0020 -0.0024 0.0054 0.4984
674 0.0003 0.0020 -0.0036 0.0042 0.2055
675 0.0025 0.0020 -0.0015 0.0064 0.8614
676 0.0003 0.0020 -0.0036 0.0042 0.1967
677 0.0010 0.0020 -0.0029 0.0049 0.3526
678 0.0015 0.0022 -0.0028 0.0057 0.5303
679 0.0030 0.0021 -0.0011 0.0070 0.9487
680 0.0007 0.0020 -0.0032 0.0046 0.2877
681 0.0003 0.0020 -0.0036 0.0042 0.1989
682 0.0003 0.0020 -0.0036 0.0042 0.2101
683 0.0010 0.0020 -0.0029 0.0049 0.3615
684 0.0013 0.0020 -0.0026 0.0052 0.4379
685 -0.0000 0.0020 -0.0039 0.0038 0.1475
686 -0.0000 0.0020 -0.0039 0.0039 0.1513
687 -0.0001 0.0020 -0.0040 0.0038 0.1446
688 0.0000 0.0020 -0.0039 0.0039 0.1584
689 0.0007 0.0020 -0.0033 0.0047 0.2922
690 0.0000 0.0020 -0.0039 0.0039 0.1588
691 0.0002 0.0020 -0.0037 0.0041 0.1875
692 0.0001 0.0020 -0.0038 0.0040 0.1632
693 0.0002 0.0020 -0.0037 0.0041 0.1827
694 0.0001 0.0020 -0.0038 0.0039 0.1627
695 0.0007 0.0020 -0.0032 0.0046 0.2855
696 0.0013 0.0020 -0.0027 0.0053 0.4462
697 0.0013 0.0020 -0.0026 0.0052 0.4470
698 0.0006 0.0020 -0.0033 0.0045 0.2647
699 0.0001 0.0020 -0.0038 0.0040 0.1630
700 0.0004 0.0020 -0.0036 0.0043 0.2261
701 0.0000 0.0020 -0.0039 0.0039 0.1588
702 0.0000 0.0020 -0.0039 0.0039 0.1592
703 0.0006 0.0020 -0.0033 0.0045 0.2710
704 0.0003 0.0020 -0.0036 0.0042 0.2097
705 0.0001 0.0020 -0.0038 0.0040 0.1737
706 0.0003 0.0020 -0.0036 0.0042 0.2071
707 -0.0000 0.0020 -0.0039 0.0039 0.1531
708 0.0002 0.0020 -0.0037 0.0041 0.1821
709 0.0020 0.0020 -0.0019 0.0060 0.6902
710 0.0007 0.0020 -0.0032 0.0046 0.2828
711 0.0010 0.0020 -0.0029 0.0050 0.3690
712 0.0024 0.0021 -0.0016 0.0064 0.8396
713 0.0003 0.0020 -0.0036 0.0042 0.2076
714 0.0001 0.0020 -0.0038 0.0040 0.1660
715 -0.0000 0.0020 -0.0039 0.0039 0.1504
716 0.0020 0.0020 -0.0019 0.0060 0.6930
717 0.0006 0.0020 -0.0033 0.0045 0.2564
718 0.0019 0.0020 -0.0021 0.0058 0.6302
719 -0.0000 0.0020 -0.0039 0.0038 0.1480
720 -0.0000 0.0020 -0.0039 0.0039 0.1489
721 0.0004 0.0020 -0.0035 0.0044 0.2320
722 0.0014 0.0021 -0.0027 0.0055 0.4899
723 0.0016 0.0021 -0.0025 0.0057 0.5460
724 0.0014 0.0023 -0.0031 0.0059 0.5340
725 0.0011 0.0020 -0.0029 0.0051 0.3976
726 0.0017 0.0021 -0.0024 0.0057 0.5676
727 0.0000 0.0020 -0.0039 0.0039 0.1577
728 0.0007 0.0020 -0.0032 0.0046 0.2931
729 0.0024 0.0020 -0.0015 0.0064 0.8451
730 0.0009 0.0020 -0.0031 0.0048 0.3287
731 0.0018 0.0020 -0.0021 0.0058 0.6169
732 0.0003 0.0020 -0.0036 0.0042 0.2025
733 0.0004 0.0020 -0.0035 0.0043 0.2205
734 0.0018 0.0020 -0.0021 0.0058 0.6229
735 0.0029 0.0020 -0.0011 0.0069 0.9745
736 0.0053 0.0021 0.0012 0.0095 0.2394
737 0.0002 0.0020 -0.0037 0.0041 0.1875
738 0.0002 0.0020 -0.0037 0.0041 0.1908
739 0.0003 0.0020 -0.0036 0.0042 0.2077
740 0.0000 0.0020 -0.0038 0.0039 0.1606
741 -0.0000 0.0020 -0.0039 0.0039 0.1516
742 0.0015 0.0020 -0.0024 0.0054 0.5046
743 0.0027 0.0021 -0.0014 0.0067 0.9427
744 0.0008 0.0020 -0.0031 0.0047 0.3170
745 0.0043 0.0021 0.0001 0.0085 0.4882
746 0.0006 0.0020 -0.0033 0.0045 0.2599
747 0.0032 0.0020 -0.0008 0.0072 0.8682
748 0.0003 0.0020 -0.0036 0.0042 0.2072
749 0.0071 0.0022 0.0028 0.0114 0.0535 *
750 0.0009 0.0020 -0.0030 0.0048 0.3310
751 0.0020 0.0021 -0.0021 0.0061 0.6921
752 0.0026 0.0020 -0.0013 0.0065 0.9138
753 0.0005 0.0020 -0.0034 0.0044 0.2337
754 0.0008 0.0020 -0.0032 0.0047 0.3092
755 -0.0000 0.0020 -0.0039 0.0038 0.1466
756 0.0017 0.0020 -0.0022 0.0056 0.5793
757 0.0002 0.0020 -0.0037 0.0041 0.1878
758 0.0006 0.0020 -0.0033 0.0045 0.2556
759 0.0000 0.0020 -0.0039 0.0039 0.1555
760 0.0010 0.0020 -0.0030 0.0050 0.3736
761 -0.0000 0.0020 -0.0039 0.0038 0.1476
762 0.0005 0.0020 -0.0034 0.0044 0.2412
763 0.0017 0.0020 -0.0023 0.0056 0.5614
764 0.0026 0.0021 -0.0016 0.0068 0.9197
765 0.0006 0.0020 -0.0033 0.0045 0.2606
766 0.0002 0.0020 -0.0037 0.0041 0.1791
767 0.0029 0.0020 -0.0010 0.0069 0.9634
768 0.0035 0.0023 -0.0010 0.0079 0.7830
769 0.0008 0.0020 -0.0032 0.0047 0.2991
770 0.0012 0.0020 -0.0028 0.0053 0.4382
771 0.0002 0.0020 -0.0037 0.0041 0.1801
772 0.0008 0.0020 -0.0031 0.0048 0.3174
773 0.0006 0.0020 -0.0033 0.0045 0.2590
774 0.0013 0.0020 -0.0026 0.0053 0.4547
775 0.0025 0.0021 -0.0016 0.0065 0.8703
776 0.0005 0.0020 -0.0034 0.0044 0.2494
777 0.0027 0.0020 -0.0012 0.0067 0.9615
778 0.0000 0.0020 -0.0039 0.0039 0.1554
779 0.0027 0.0020 -0.0013 0.0067 0.9391
780 0.0011 0.0020 -0.0028 0.0051 0.3933
781 0.0001 0.0020 -0.0038 0.0040 0.1671
782 0.0005 0.0020 -0.0035 0.0044 0.2429
783 0.0008 0.0020 -0.0031 0.0047 0.3111
784 0.0009 0.0020 -0.0030 0.0048 0.3406
785 -0.0000 0.0020 -0.0039 0.0039 0.1482
786 0.0023 0.0021 -0.0018 0.0064 0.7846
787 0.0003 0.0020 -0.0036 0.0042 0.2097
788 0.0000 0.0020 -0.0039 0.0039 0.1592
789 0.0055 0.0022 0.0012 0.0098 0.2259
790 0.0014 0.0020 -0.0026 0.0054 0.4892
791 0.0028 0.0021 -0.0013 0.0069 0.9918
792 -0.0001 0.0020 -0.0040 0.0038 0.1436
793 0.0011 0.0020 -0.0028 0.0050 0.3956
794 0.0018 0.0022 -0.0026 0.0062 0.6540
795 -0.0000 0.0020 -0.0039 0.0039 0.1493
796 0.0005 0.0020 -0.0034 0.0044 0.2499
797 0.0012 0.0020 -0.0028 0.0052 0.4157
798 0.0002 0.0020 -0.0037 0.0040 0.1769
799 -0.0000 0.0020 -0.0039 0.0039 0.1505
800 0.0001 0.0020 -0.0037 0.0040 0.1753
801 0.0006 0.0020 -0.0033 0.0045 0.2607
802 0.0004 0.0020 -0.0035 0.0042 0.2127
803 0.0020 0.0021 -0.0021 0.0060 0.6738
804 0.0000 0.0020 -0.0039 0.0039 0.1577
805 0.0004 0.0020 -0.0035 0.0043 0.2248
806 0.0348 0.0038 0.0273 0.0423 0.0000 ***
807 0.0244 0.0037 0.0172 0.0316 0.0000 ***
808 0.0010 0.0020 -0.0029 0.0049 0.3634
809 0.0004 0.0020 -0.0035 0.0043 0.2249
810 0.0028 0.0020 -0.0011 0.0068 0.9991
811 0.0006 0.0020 -0.0033 0.0045 0.2619
812 0.0000 0.0020 -0.0038 0.0039 0.1601
813 0.0022 0.0020 -0.0018 0.0062 0.7477
814 0.0003 0.0020 -0.0036 0.0042 0.2109
815 0.0272 0.0036 0.0202 0.0342 0.0000 ***
816 0.0323 0.0039 0.0246 0.0399 0.0000 ***
817 0.0007 0.0020 -0.0032 0.0046 0.2755
818 0.0004 0.0020 -0.0035 0.0043 0.2303
819 0.0024 0.0020 -0.0016 0.0063 0.8164
820 0.0030 0.0021 -0.0011 0.0071 0.9386
821 0.0134 0.0025 0.0085 0.0182 0.0000 ***
822 0.0063 0.0021 0.0021 0.0104 0.1080
823 0.0003 0.0020 -0.0036 0.0042 0.2043
824 0.0002 0.0020 -0.0037 0.0041 0.1869
825 0.0036 0.0020 -0.0004 0.0076 0.6898
826 0.0059 0.0022 0.0016 0.0101 0.1665
827 0.0030 0.0021 -0.0011 0.0071 0.9421
828 0.0001 0.0020 -0.0038 0.0040 0.1723
829 0.0005 0.0020 -0.0034 0.0044 0.2466
830 0.0001 0.0020 -0.0038 0.0040 0.1631
831 0.0012 0.0020 -0.0028 0.0051 0.3998
==============================================================================
Significant units: 7 / 832
---
Signif. codes: 0 '***' 0.01 '**' 0.05 '*' 0.1 ' ' 1
==============================================================================
Group Importance
[8]:
res_df = fdfi_estimator.conf_int(
alpha=0.05,
target="X",
groups=df_groups,
threshold_null=True,
var_floor_c=0.1,
var_floor_method="fixed",
margin=0.0,
margin_method="fixed",
alternative="two-sided",
multitest_method="bonferroni",
verbose=False,
)
res_df = pd.DataFrame({
"group": res_df["groups"],
"importance": res_df["score"],
"se": res_df["se"],
"zscore": res_df["zscore"],
"ci_lower": res_df["ci_lower"],
"ci_upper": res_df["ci_upper"],
"p_value": res_df["pvalue"],
"p_value_adj": res_df.get("pvalue_adj", res_df["pvalue"]),
"reject_null": res_df["reject_null"],
})
Group Summary Table
[9]:
print("=== X-space group summary ===")
_ = fdfi_estimator.summary(
alpha=0.05,
target="X",
groups=df_groups,
threshold_null=True,
var_floor_c=0.1,
var_floor_method="fixed",
margin=0.0,
margin_method="fixed",
alternative="two-sided",
multitest_method="bonferroni",
)
print("\n=== Z-space group summary ===")
_ = fdfi_estimator.summary(
alpha=0.05,
target="Z",
groups=df_groups,
threshold_null=True,
var_floor_c=0.1,
var_floor_method="fixed",
margin=0.0,
margin_method="fixed",
alternative="two-sided",
multitest_method="bonferroni",
)
=== X-space group summary ===
==============================================================================
Feature Importance Results
==============================================================================
Method: EOTExplainer
Number of units: 14
Significance level: 0.05
Alternative: two-sided
Multiple testing: bonferroni
Margin method: fixed
------------------------------------------------------------------------------
Group Estimate Std Err CI Lower CI Upper Adj P-val Sig
------------------------------------------------------------------------------
cd4bs 0.1073 0.0097 0.0883 0.1262 0.0000 ***
covar 0.2089 0.0161 0.1774 0.2403 0.0000 ***
cysteines 0.0119 0.0042 0.0037 0.0201 0.0616 *
esa 0.0983 0.0088 0.0810 0.1156 0.0000 ***
geog 0.0031 0.0041 -0.0048 0.0111 1.0000
geometry 0.0359 0.0050 0.0262 0.0456 0.0000 ***
glyco 0.0541 0.0058 0.0428 0.0654 0.0000 ***
gp41 0.0270 0.0048 0.0176 0.0364 0.0000 ***
pngs 0.1721 0.0140 0.1447 0.1995 0.0000 ***
pngs_novrc01 0.0867 0.0069 0.0732 0.1002 0.0000 ***
sequons 0.0372 0.0049 0.0275 0.0468 0.0000 ***
steric_bulk 0.0064 0.0041 -0.0016 0.0145 1.0000
subtype 0.0087 0.0041 0.0006 0.0167 0.4937
vrc01 0.1163 0.0100 0.0966 0.1360 0.0000 ***
==============================================================================
Significant units: 10 / 14
---
Signif. codes: 0 '***' 0.01 '**' 0.05 '*' 0.1 ' ' 1
==============================================================================
=== Z-space group summary ===
==============================================================================
Feature Importance Results
==============================================================================
Method: EOTExplainer
Number of units: 14
Significance level: 0.05
Alternative: two-sided
Multiple testing: bonferroni
Margin method: fixed
------------------------------------------------------------------------------
Group Estimate Std Err CI Lower CI Upper Adj P-val Sig
------------------------------------------------------------------------------
cd4bs 0.0915 0.0096 0.0727 0.1102 0.0000 ***
covar 0.1943 0.0163 0.1624 0.2262 0.0000 ***
cysteines 0.0202 0.0045 0.0114 0.0290 0.0001 ***
esa 0.0841 0.0086 0.0672 0.1010 0.0000 ***
geog 0.0019 0.0041 -0.0061 0.0098 1.0000
geometry 0.0659 0.0072 0.0519 0.0800 0.0000 ***
glyco 0.0405 0.0058 0.0291 0.0519 0.0000 ***
gp41 0.0231 0.0049 0.0134 0.0328 0.0000 ***
pngs 0.1471 0.0137 0.1202 0.1739 0.0000 ***
pngs_novrc01 0.0950 0.0076 0.0801 0.1100 0.0000 ***
sequons 0.0666 0.0071 0.0527 0.0804 0.0000 ***
steric_bulk 0.0125 0.0043 0.0040 0.0209 0.0521 *
subtype 0.0054 0.0042 -0.0028 0.0135 1.0000
vrc01 0.0988 0.0098 0.0796 0.1180 0.0000 ***
==============================================================================
Significant units: 11 / 14
---
Signif. codes: 0 '***' 0.01 '**' 0.05 '*' 0.1 ' ' 1
==============================================================================
Group Mapping
[10]:
group_mapping = pd.DataFrame({
"group_num": range(1, 15),
"group": [
"vrc01", "cd4bs", "esa", "glyco", "covar", "pngs", "gp41",
"pngs_novrc01", "subtype", "sequons", "geometry", "cysteines",
"steric_bulk", "geog"
],
"description": [
"VRC01 binding footprint",
"CD4 binding sites",
"Sites with sufficient exposed surface area",
"Sites identified as important for glycosylation",
"Sites with residues that covary with\nthe VRC01 binding footprint",
"Sites associated with VRC01-specific\npotential N-linked glycosylation (PNGS) effects",
"gp41 sites important for VRC01 binding",
"Sites for indicating N-linked glycosylation",
"Majority virus subtypes",
"Region-specific counts of PNGS",
"Viral geometry",
"Cysteine counts",
"Steric bulk at critical locations",
"Geographic confounders",
],
})
Group Importance Plot
[11]:
DATASET_LABELS = {
"sens50": "Sensitivity 50",
"sens80": "Sensitivity 80",
"ic50": "IC50 Censored",
}
dataset_label = DATASET_LABELS.get(outcome, outcome)
group_df_sorted = res_df.sort_values("importance", ascending=True).reset_index(drop=True)
group_df_sorted = group_df_sorted.merge(group_mapping, on="group", how="left")
fig, axes = plt.subplots(1, 3, figsize=(18, 6), gridspec_kw={"width_ratios": [3, 3, 3]})
fig.suptitle(
f"{dataset_label} ({outcome}) - EOT FDFI Group Importance",
fontsize=22,
y=1.04,
)
group_numbers = list(group_df_sorted["group_num"])
ax1 = axes[0]
ax1.barh(
range(len(group_df_sorted)),
group_df_sorted["importance"],
xerr=group_df_sorted["se"],
error_kw=dict(capsize=5),
alpha=0.7,
color="steelblue",
)
ax1.set_yticks(range(len(group_df_sorted)))
ax1.set_yticklabels(group_numbers, fontsize=12)
ax1.set_xlabel("Group Importance", fontsize=16)
ax1.set_title("Feature Group Importance (EOT FDFI)", fontsize=18)
ax1.set_ylabel("Group Number", fontsize=16)
ax1.grid(axis="x", alpha=0.3)
for i, (_, row) in enumerate(group_df_sorted.iterrows()):
if row["reject_null"]:
ax1.text(
row["importance"] + row["se"] + 0.001,
i,
"*",
va="center",
fontweight="bold",
color="red",
)
ax2 = axes[1]
colors = ["red" if reject_null else "gray" for reject_null in group_df_sorted["reject_null"]]
ax2.barh(range(len(group_df_sorted)), group_df_sorted["zscore"], alpha=0.7, color=colors)
ax2.set_yticks(range(len(group_df_sorted)))
ax2.set_yticklabels(group_numbers, fontsize=12)
ax2.set_xlabel("Z-score", fontsize=16)
ax2.set_title("Feature Group Z-scores", fontsize=18)
ax2.grid(axis="x", alpha=0.3)
ax2.axvline(x=1.96, color="red", linestyle="--", linewidth=2, alpha=0.7, label="p=0.05")
ax2.legend(fontsize=12)
ax3 = axes[2]
ax3.set_xlim(0, 1)
ax3.set_ylim(-0.5, len(group_df_sorted) - 0.5)
for i, (_, row) in enumerate(group_df_sorted.iterrows()):
group_name = row["group"]
display_name = row["description"] if pd.notna(row["description"]) else group_name
text_color = "red" if row["reject_null"] else "gray"
ax3.text(
0.02,
i,
f"{int(row['group_num']):2d}.",
va="center",
ha="left",
fontsize=14,
fontweight="bold",
color="black",
)
ax3.text(
0.09,
i,
display_name,
va="center",
ha="left",
fontsize=12,
color=text_color,
)
ax3.set_yticks([])
ax3.set_xticks([])
ax3.set_title("Feature Group Annotations", fontsize=18)
for spine in ax3.spines.values():
spine.set_visible(False)
plt.tight_layout(rect=[0, 0, 1, 0.95])
plt.show()
Summary
This notebook applies EOT FDFI (Entropic Optimal Transport Disentangled Feature Importance) with 5-fold cross-fitting to the sens50 HIV neutralization dataset (d=832 binary features, n≈300).
Why EOT over FlowMatching?
FlowExplainer X-space attribution relies on the flow Jacobian H = dX/dZ. For binary high-d data (d >> n), H≈I (near-identity), making X-space DFI unreliable. EOTExplainer uses an analytical whitening map and coupling moments — no Jacobian issues.
Results (α = 0.05, Bonferroni correction over 14 groups):
See the group summary table and plot above for significant feature groups.
[12]:
print("=== Group-level results (matching DFI paper) ===")
print(f"{'Group':<20} {'Importance':>12} {'SE':>10} {'Z-score':>10} {'Significant':>12}")
print("-" * 70)
for _, row in res_df.sort_values("zscore", ascending=False).iterrows():
sig = "***" if row["reject_null"] else ""
print(f"{row['group']:<20} {row['importance']:>12.4f} {row['se']:>10.4f} {row['zscore']:>10.2f} {sig:>12}")
n_sig = res_df["reject_null"].sum()
print(f"\nSignificant groups: {n_sig}/{len(res_df)} (Bonferroni alpha=0.05)")
print(f"Z-score range: {res_df['zscore'].min():.2f} to {res_df['zscore'].max():.2f}")
=== Group-level results (matching DFI paper) ===
Group Importance SE Z-score Significant
----------------------------------------------------------------------
covar 0.2089 0.0161 13.01 ***
pngs_novrc01 0.0867 0.0069 12.61 ***
pngs 0.1721 0.0140 12.29 ***
vrc01 0.1163 0.0100 11.59 ***
esa 0.0983 0.0088 11.15 ***
cd4bs 0.1073 0.0097 11.09 ***
glyco 0.0541 0.0058 9.37 ***
sequons 0.0372 0.0049 7.54 ***
geometry 0.0359 0.0050 7.23 ***
gp41 0.0270 0.0048 5.64 ***
cysteines 0.0119 0.0042 2.85
subtype 0.0087 0.0041 2.11
steric_bulk 0.0064 0.0041 1.57
geog 0.0031 0.0041 0.78
Significant groups: 10/14 (Bonferroni alpha=0.05)
Z-score range: 0.78 to 13.01